ArticleGenome biology and evolution2014
Efficient purging of deleterious mutations in plants with haploid selfing.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Outcrossing Complicates Mutation Purging by Trapping Single Nucleotide Polymorphisms in Structural Variant Mutations.bioRxiv : the preprint server for biology · 2025Article
- Can ploidy changes propel the evolution of allogamy in a selfing species complex?BMC plant biology · 2025Article
- Selfing Shapes Fixation of a Mutant Allele Under Flux Equilibrium.Genome biology and evolution · 2024Article
- Parallel loss of sexual reproduction in field populations of a brown alga sheds light on the mechanisms underlying the emergence of asexuality.Nature ecology & evolution · 2024Article
- Linked Selection and Gene Density Shape Genome-Wide Patterns of Diversification in Peatmosses.Evolutionary applications · 2024Article
- The Ka /Ks and πa /πs Ratios under Different Models of Gametophytic and Sporophytic Selection.Genome biology and evolution · 2023Article
- Genomic Features of Parthenogenetic Animals.The Journal of heredity · 2021Article
- Article
- Slow evolution of sex-biased genes in the reproductive tissue of the dioecious plant Salix viminalis.Molecular ecology · 2018Article
- Variation in rates of spontaneous male production within the nematode species Pristionchus pacificus supports an adaptive role for males and outcrossing.BMC evolutionary biology · 2017Article
- Hemizygosity Enhances Purifying Selection: Lack of Fast-Z Evolution in Two Satyrine Butterflies.Genome biology and evolution · 2016Article
- Transcriptomes of Plant Gametophytes Have a Higher Proportion of Rapidly Evolving and Young Genes than Sporophytes.Molecular biology and evolution · 2016Article
- Article
- Balance between inbreeding and outcrossing in a nannandrous species, the moss Homalothecium lutescens.Heredity · 2016Article
- Lineage-specific sequence evolution and exon edge conservation partially explain the relationship between evolutionary rate and expression level in A. thaliana.Molecular ecology · 2015Article
- The evolution of selfing is accompanied by reduced efficacy of selection and purging of deleterious mutations.Genetics · 2015Article
- The male germline of angiosperms: repertoire of an inconspicuous but important cell lineage.Frontiers in plant science · 2015Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In diploid organisms, selfing reduces the efficiency of selection in removing deleterious mutations from a population. This need not be the case for all organisms. Some plants, for example, undergo an extreme form of selfing known as intragametophytic selfing, which immediately exposes all recessive deleterious mutations in a parental genome to selective purging. Here, we ask how effectively deleterious mutations are removed from such plants. Specifically, we study the extent to which deleterious mutations accumulate in a predominantly selfing and a predominantly outcrossing pair of moss species, using genome-wide transcriptome data. We find that the selfing species purge significantly more nonsynonymous mutations, as well as a greater proportion of radical amino acid changes which alter physicochemical properties of amino acids. Moreover, their purging of deleterious mutation is especially strong in conserved regions of protein-coding genes. Our observations show that selfing need not impede but can even accelerate the removal of deleterious mutations, and do so on a genome-wide scale.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.