ArticleMolecular biology reports2014
Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia).
Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 17 citations in OpenAlex.
- Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians.Metabolism open · 2024Article
- Beyond the CNS: The many peripheral roles of APOE.Neurobiology of disease · 2020Review
- TheBalkan journal of medical genetics : BJMG · 2017Article
- Emerging risk biomarkers in cardiovascular diseases and disorders.Journal of lipids · 2015Review
- The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men.PloS one · 2014Article
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7 authors at 2 institutions in 1 country.
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Abstract
The metabolic syndrome (MetS) is a polygenic multifactorial metabolic disorder with strong socioeconomic influence. MetS has became a worldwide epidemic, that directly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The human apoE gene, coding Apolipoprotein E, has three common polymorphisms in human population: e2, e3 and e4, which are proved to be associated with impaired lipid metabolism. The contribution of apoE polymorphism to MetS disorders has not been investigated previously in Vojvodina Province, region with the highest number of obese people in Serbia. The aim of this study was to evaluate apoE gene polymorphism in relation to MetS disorders. The healthy control group of 30 individuals and 63 MetS patients were examined for apoE variants in relation to biochemical and anthropometric parameters. The genotypes were determined by PCR-RFLP. Regarding all parameters, significantly higher values were detected in MetS group compared to control. The MetS group of patients had significantly higher frequency of e4 allele. In addition, positive relation was revealed between e4 allele presence and all measured parameters. It was found that the e4 allele was related with a significantly increased OR of MetS disorders according to the International Diabetes Federation definition. These results suggested that e4 allele may act as a one of determinants for development of metabolic syndrome.
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