ArticleJournal of musculoskeletal & neuronal interactions2014
Muscle density predicts changes in bone density and strength: a prospective study in girls.
Article in Journal of musculoskeletal & neuronal interactions, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Trial
- Non-lethal imaging and modeling approaches for estimating dry mass in aquatic larvae.PloS one · 2026Article
- Hormonal Influences on Skeletal Muscle Function in Women across Life Stages: A Systematic Review.Muscles (Basel, Switzerland) · 2024Review
- Association Between the Growth Hormone/Insulin-Like Growth Factor-1 Axis and Muscle Density in Children and Adolescents of Short Stature.Frontiers in endocrinology · 2022Article
- A systematic review and meta-analysis of pediatric normative peripheral quantitative computed tomography data.Bone reports · 2021Review
- Anterior Cruciate Ligament Research Retreat VIII Summary Statement: An Update on Injury Risk Identification and Prevention Across the Anterior Cruciate Ligament Injury Continuum, March 14-16, 2019, Greensboro, NC.Journal of athletic training · 2019Article
- Mechanical basis of bone strength: influence of bone material, bone structure and muscle action.Journal of musculoskeletal & neuronal interactions · 2017Review
- Adverse Fat Depots and Marrow Adiposity Are Associated With Skeletal Deficits and Insulin Resistance in Long-Term Survivors of Pediatric Hematopoietic Stem Cell Transplantation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveWe sought to determine whether muscle density, an index of skeletal muscle fat content, was predictive of 2-year changes in weight-bearing bone parameters in young girls.
methodsTwo-year prospective data from 248 girls, aged 8-13 years at baseline. Peripheral quantitative computed tomography was used to measure changes in bone strength indices (bone strength index [BSI, mg(2)/mm(4)] and strength-strain index [SSIp, mm(3)]) and volumetric bone mineral density [vBMD, mg/cm(3)] at distal metaphyseal and diaphyseal regions of the femur and tibia, as well as calf and thigh muscle density (mg/cm(3)), and muscle cross-sectional area (MCSA, mm(2)), indices of skeletal muscle fat content and muscle force production, respectively.
resultsAfter controlling for potential confounders, greater gains in femur BSI (44%, P<0.002), total femur vBMD (114%, P<0.04) and femur trabecular vBMD (306%, P<0.002) occurred in girls in the lowest versus the highest groups of baseline thigh muscle density. Greater gains in tibial BSI (25%, P<0.03) and trabecular vBMD (190%, P<0.002) were also observed in the lowest versus the highest baseline calf muscle density groups.
conclusionBaseline muscle density is a significant predictor of changes in bone density and bone strength in young girls during a period of rapid skeletal development.
Indexed as
Identifiers
24879023PMC4414028W2403297299What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.