Evidence map›Paper›PMID 24878972›Full record

ReviewNeuro endocrinology letters2014

Cervical neuroendocrine tumor in a young female with Lynch Syndrome.

Ibraheem Yousef, Fadi Siyam, Lester Layfield, Carl Freter, James R Sowers

Abstract readCase ReportsReview
In one paragraph

Review in Neuro endocrinology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ibraheem YousefDepartment of Medicine, Internal Medicine, University of Missouri, Columbia, MO, USA.
Fadi SiyamDiabetes and Cardiovascular Center, University of Missouri, Columbia, MO, USA.
Lester LayfieldDepartment of Pathology, University of Missouri, Columbia, MO, USA.
Carl FreterDivision of Hematology and Oncology, University of Missouri, Columbia, MO, USA.
James R SowersDepartment of Medicine, Internal Medicine, University of Missouri, Columbia, MO, USA.
University of Missouri · US

Funding

ANG II OPPOSES INS MEDIATED VASORELAXATION &GLU UTILZAR01HL073101 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2004 to 2013
$2.7M
Ang II and Overnutrition and Insulin resistance in Cardiovascular TissueR01HL107910 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2011 to 2015
$1.8M
Interactions of the RAAS and a Western Diet on Insulin Metabolic ActionsI01BX001981 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI LASTRA, GUIDO · 2013 to 2022
–
NHLBI NIH HHS HL107910NHLBI NIH HHS HL73101NHLBI NIH HHS R01 HL073101NHLBI NIH HHS R01 HL107910
6 · The paper itself

Abstract

Neuroendocrine tumors rarely occur in the cervix or other components of the reproductive system. These tumors have been associated with microsatellite instability, are very aggressive and often associated with poor outcome. Lynch syndrome is an inherited cancer syndrome that has also been associated with microsatellite instability. Here we report a 34-year-old female with Lynch syndrome and a family history of loss of DNA mismatch of the hereditary non-polyposis colorectal cancer repair gene expression who presented with a neuroendocrine tumor of her cervix as the first manifestation of Lynch syndrome. This is the first case reported of a neuroendocrine tumor of the cervix in a patient with Lynch syndrome. We also review the relationship between Lynch Syndrome and neuroendocrine tumors.

Indexed as

Adaptor Proteins, Signal TransducingAdultColorectal Neoplasms, Hereditary NonpolyposisDNA Mismatch RepairFatal OutcomeFemaleHumansMutL Protein Homolog 1Neuroendocrine TumorsNuclear ProteinsUterine Cervical NeoplasmsAdaptor Proteins, Signal TransducingMLH1 protein, humanMutL Protein Homolog 1Nuclear Proteins

Identifiers

PMID24878972
PMCPMC4308043
OpenAlexW2164206465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.