ArticleApplied and environmental microbiology2014
Biomineralization of uranium by PhoY phosphatase activity aids cell survival in Caulobacter crescentus.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Heterotrophic bacterial bioleaching and sequestration of uranium from mineral resources: a review.Frontiers in microbiology · 2026Review
- High-affinity amide-lanthanide adsorption to gram-positive soil bacteria.Environmental microbiology reports · 2023Article
- Impact of microbial processes on the safety of deep geological repositories for radioactive waste.Frontiers in microbiology · 2023Review
- Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria.The ISME journal · 2022Article
- Molecular Mechanisms Underlying Bacterial Uranium Resistance.Frontiers in microbiology · 2022Review
- Emerging investigator series: entrapment of uranium-phosphorus nanocrystals inside root cells ofEnvironmental science. Processes & impacts · 2021Article
- Isolation and Identification of Uranium Tolerant Phosphate-SolubilizingFrontiers in microbiology · 2021Article
- Is Long-Term Heavy Metal Exposure Driving Carriage of Antibiotic Resistance in Environmental Opportunistic Pathogens: A Comprehensive Phenomic and Genomic Assessment UsingFrontiers in microbiology · 2020Article
- Article
- Genomic traits of Klebsiella oxytoca DSM 29614, an uncommon metal-nanoparticle producer strain isolated from acid mine drainages.BMC microbiology · 2018Article
- Article
- Two Outer Membrane Proteins Contribute to Caulobacter crescentus Cellular Fitness by Preventing Intracellular S-Layer Protein Accumulation.Applied and environmental microbiology · 2016Article
- Effects of long-term radionuclide and heavy metal contamination on the activity of microbial communities, inhabiting uranium mining impacted soils.Environmental science and pollution research international · 2016Article
- Transposon Mutagenesis Paired with Deep Sequencing of Caulobacter crescentus under Uranium Stress Reveals Genes Essential for Detoxification and Stress Tolerance.Journal of bacteriology · 2015Article
- Fe biomineralization mirrors individual metabolic activity in a nitrate-dependent Fe(II)-oxidizer.Frontiers in microbiology · 2015Article
- Modulation of medium pH by Caulobacter crescentus facilitates recovery from uranium-induced growth arrest.Applied and environmental microbiology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caulobacter crescentus is known to tolerate high levels of uranium [U(VI)], but its detoxification mechanism is poorly understood. Here we show that C. crescentus is able to facilitate U(VI) biomineralization through the formation of U-Pi precipitates via its native alkaline phosphatase activity. The U-Pi precipitates, deposited on the cell surface in the form of meta-autunite structures, have a lower U/Pi ratio than do chemically produced precipitates. The enzyme that is responsible for the phosphatase activity and thus the biomineralization process is identified as PhoY, a periplasmic alkaline phosphatase with broad substrate specificity. Furthermore, PhoY is shown to confer a survival advantage on C. crescentus toward U(VI) under both growth and nongrowth conditions. Results obtained in this study thus highlight U(VI) biomineralization as a resistance mechanism in microbes, which not only improves our understanding of bacterium-mineral interactions but also aids in defining potential ecological niches for metal-resistant bacteria.
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