Evidence map›Paper›PMID 24878525›Full record

ArticleBiochemical and biophysical research communications2014

Influenza entry pathways in polarized MDCK cells.

Yueting Zhang, Gary R Whittaker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Viruses · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yueting ZhangDepartment of Microbiology & Immunology, Cornell University, Ithaca, NY 14853, USA.
Gary R WhittakerDepartment of Microbiology & Immunology, Cornell University, Ithaca, NY 14853, USA. Electronic address: grw7@cornell.edu.
Cornell University · US

Funding

Endocytosis of Influenza VirusesR01AI048678 · NIAID · CORNELL UNIVERSITY ITHACA · PI WHITTAKER, GARY R · 2001 to 2011
$3.4M
TRAINING IN MOLECULAR VIROLOGY AND PATHOGENESIST32AI007618 · NIAID · CORNELL UNIVERSITY ITHACA · PI PARRISH, COLIN R. · 2000 to 2010
$1.4M
NIAID NIH HHS R01 AI048678NIAID NIH HHS R01 AI48678NIAID NIH HHS T32 AI007618NIAID NIH HHS T32AI007618
6 · The paper itself

Abstract

In non-polarized cell culture models, influenza virus has been shown to enter host cells via multiple endocytic pathways, including classical clathrin-mediated endocytic routes (CME), clathrin- and caveolae-independent routes and macropinocytosis. However, little is known about the entry route of influenza virus in differentiated epithelia, in vivo site of infection for influenza virus. Here, we show that in polarized Madin-Darby canine kidney type II (MDCK II) cells, influenza virus has a specific utilization of the clathrin-mediated endocytic pathway and requires Eps15 for host cell entry.

Indexed as

EndocytosisSignal TransductionVirus InternalizationAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsCell PolarityClathrinDogsInfluenza A Virus, H1N1 SubtypeMadin Darby Canine Kidney CellsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportClathrinEPN2 protein, humanClathrinInfluenza virusPolarized cellVirus entry

Identifiers

PMID24878525
PMCPMC4107043
OpenAlexW2113883201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.