Evidence map›Paper›PMID 24877244›Full record

ReviewMolecular oral microbiology2014

Innocent until proven guilty: mechanisms and roles of Streptococcus-Candida interactions in oral health and disease.

H Xu, H F Jenkinson, A Dongari-Bagtzoglou

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular oral microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. HApplied and environmental microbiology · 2026
    Article
  4. Article
  5. AJournal of bacteriology · 2026
    Review
  6. Article
  7. Streptococcus dentisani inhibits the growth of Candida albicans and Candida glabrata: in vitro assay.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  8. Microbiome variability and role ofJournal of oral microbiology · 2025
    Article
  9. Article
  10. Insights into the enigma of oral streptococci in carcinogenesis.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Microorganisms · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Interkingdom assemblages in human saliva display group-level surface mobility and disease-promoting emergent functions.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

H Xu
H F Jenkinson
A Dongari-Bagtzoglou
University of Connecticut · USUniversity of Bristol · GB

Funding

Oral Epithelial Cells, Candida and PMN ActivationR01DE013986 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Anna I Dongari-Bagtzoglou · 2000 to 2026
$9.2M
Streptococcus-Candida Communication in Oral BiofilmsR01DE016690 · NIDCR · UNIVERSITY OF BRISTOL · PI JENKINSON, HOWARD F, LAMONT, RICHARD J · 2006 to 2016
$3.8M
NIDCR NIH HHS DE013986NIDCR NIH HHS DE016690NIDCR NIH HHS R01 DE013986NIDCR NIH HHS R01 DE016690
6 · The paper itself

Abstract

Candida albicans and streptococci of the mitis group colonize the oral cavities of the majority of healthy humans. While C. albicans is considered an opportunistic pathogen, streptococci of this group are broadly considered avirulent or even beneficial organisms. However, recent evidence suggests that multi-species biofilms with these organisms may play detrimental roles in host homeostasis and may promote infection. In this review we summarize the literature on molecular interactions between members of this streptococcal group and C. albicans, with emphasis on their potential role in the pathogenesis of opportunistic oral mucosal infections.

Indexed as

Bacterial AdhesionCandida albicansCoinfectionHumansMicrobial InteractionsMouth DiseasesOral HealthStreptococcusVirulence

Identifiers

PMID24877244
PMCPMC4238848
OpenAlexW2067475510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.