Evidence map›Paper›PMID 24877201›Full record

ArticleArthritis care & research2014

Cardiovascular risk factors in women with primary Sjögren's syndrome: United Kingdom primary Sjögren's syndrome registry results.

M Juarez, T E Toms, P de Pablo, S Mitchell, S Bowman, P Nightingale, E J Price, B Griffiths, J Hunter, M Gupta and 14 more

Open access · hybridAbstract read
In one paragraph

Article in Arthritis care & research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
  2. Article
  3. Sjogren's Disease and Elevated Cardiovascular Risk: Mechanisms and Treatment.Journal of cardiovascular development and disease · 2025
    Review
  4. Observational
  5. Lipid Metabolism: An Emerging Player in Sjögren's Syndrome.Clinical reviews in allergy & immunology · 2025
    Review
  6. Article
  7. Review
  8. Hypertension in connective tissue disease.Journal of human hypertension · 2024
    Review
  9. Article
  10. Article
  11. Chronic rheumatologic disorders and cardiovascular disease risk in women.American heart journal plus : cardiology research and practice · 2023
    Review
  12. Article
  13. Observational
  14. Cardiac involvement in primary Sjӧgren's syndrome.Rheumatology international · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 12 institutions in 1 country.

M Juarez
T E Toms
P de Pablo
S Mitchell
S Bowman
P Nightingale
E J Price
B Griffiths
J Hunter
M Gupta
M Bombardieri
N Sutdliffe
C Pitzalis
C Pease
J Andrews
P Emery
M Regan
I Giles
D Isenberg
R Moots
K S Collins
W F Ng
G D Kitas
UK Primary Sjögren’s Syndrome Registry
Newcastle University · GBBarts Health NHS Trust · GBNIHR Leeds Musculoskeletal Biomedical Research Unit · GBGartnavel General Hospital · GBNIHR Surgical Reconstruction and Microbiology Research Centre · GBUniversity College London · GBUniversity of Birmingham · GBAintree University Hospitals NHS Foundation Trust · GBDudley Group NHS Foundation Trust · GBGreat Western Hospitals NHS Foundation Trust · GBRoyal Derby Hospital · GBUniversity of Manchester · GB

Funding

Medical Research Council G0800629Versus Arthritis 18475
6 · The paper itself

Abstract

objectiveTo determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well-characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.

methodsData on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.

resultsPrimary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age- and sex-matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.

conclusionPrimary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age- and sex-matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.

Indexed as

RegistriesAdultAgedCardiovascular DiseasesCohort StudiesFemaleHumansHypertensionHypertriglyceridemiaMaleMiddle AgedProspective StudiesRisk FactorsSjogren's SyndromeUnited Kingdom

Identifiers

PMID24877201
PMCPMC4529667
OpenAlexW1569529715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.