ReviewBioMed research international2014
Calcium influx and male fertility in the context of the sperm proteome: an update.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03307655 (Relationship Between Nitric Oxide), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship Between Nitric Oxide (NO) in Follicular Fluid and Sperm Fertilization Ability
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Networks Models of Actin Dynamics during Spermatozoa Postejaculatory Life: A Comparison among Human-Made and Text Mining-Based Models.BioMed research international · 2016Pooled it
- Article
- Techniques to Determine Mammalian Sperm Capacitation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health.Frontiers in endocrinology · 2025Review
- Immune stress and diet influence reproductive fitness in male tuatara (Current zoology · 2024Article
- The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-CaToxics · 2024Article
- Calcium oscillations and mitochondrial enzymes in stem cells.Regenerative therapy · 2024Review
- Proteomics Evaluation of Semen of Clinically Healthy Beagle-Breed Dogs.Veterinary sciences · 2022Article
- Review
- Recombinant human OVGP1 increases intracellular calcium and further potentiates the effects of progesterone on human sperm.Journal of assisted reproduction and genetics · 2022Article
- Review
- Calcium selective channel TRPV6: Structure, function, and implications in health and disease.Gene · 2022Review
- The role of oviduct-specific glycoprotein (OVGP1) in modulating biological functions of gametes and embryos.Histochemistry and cell biology · 2022Review
- Emerging Role of TCA Cycle-Related Enzymes in Human Diseases.International journal of molecular sciences · 2021Review
- Progesterone, Myo-Inositol, Dopamine and Prolactin Present in Follicular Fluid Have Differential Effects on Sperm Motility Subpopulations.Life (Basel, Switzerland) · 2021Article
- Current markers for infertility in men.JBRA assisted reproduction · 2021Article
- The Medical Benefits of Vitamin KNutrients · 2021Review
- Article
- The Molecular Machinery of Gametogenesis in Geodia Demosponges (Porifera): Evolutionary Origins of a Conserved Toolkit across Animals.Molecular biology and evolution · 2020Article
- The Effects of EGTA on the Quality of Fresh and Cryopreserved-Thawed Human Spermatozoa.Iranian journal of medical sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Freshly ejaculated spermatozoa are incapable or poorly capable of fertilizing an oocyte. The fertilization aptness of spermatozoa depends on the appropriate and time-dependent acquisition of hyperactivation, chemotaxis, capacitation, and the acrosome reaction, where calcium (Ca(2+)) is extensively involved in almost every step. A literature review showed that several ion channel proteins are likely responsible for regulation of the Ca(2+) uptake in spermatozoa. Therefore, manipulation of the functions of channel proteins is closely related to Ca(2+) influx, ultimately affecting male fertility. Recently, it has been shown that, together with different physiological stimuli, protein-protein interaction also modifies the Ca(2+) influx mechanism in spermatozoa. Modern proteomic analyses have identified several sperm proteins, and, therefore, these findings might provide further insight into understanding the Ca(2+) influx, protein functions, and regulation of fertility. The objective of this review was to synthesize the published findings on the Ca(2+) influx mechanism in mammalian spermatozoa and its implications for the regulation of male fertility in the context of sperm proteins. Finally, Pathway Studio (9.0) was used to catalog the sperm proteins that regulate the Ca(2+) influx signaling by using the information available from the PubMed database following a MedScan Reader (5.0) search.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.