ReviewBioMed research international2014
Cartilage repair surgery: outcome evaluation by using noninvasive cartilage biomarkers based on quantitative MRI techniques?
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Correlation and Comparative Evaluation of MOCART and MOCART 2.0 for Assessing Cartilage Repair.Medicina (Kaunas, Lithuania) · 2025Article
- MR imaging after patellar MACI and MPFL reconstruction: a comparison of isolated versus combined procedures.Skeletal radiology · 2024Article
- 3-Tesla T2 Mapping Magnetic Resonance Imaging for Evaluation of SLAP Lesions in Patients with Shoulder Pain: An Arthroscopy-Controlled Study.Journal of clinical medicine · 2023Article
- Correlation of Postoperative Imaging With MRI and Clinical Outcome After Cartilage Repair of the Ankle: A Systematic Review and Meta-analysis.Foot & ankle orthopaedics · 2022Article
- Review of Quantitative Knee Articular Cartilage MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Patellar instability MRI measurements are associated with knee joint degeneration after reconstruction of the medial patellofemoral ligament.Skeletal radiology · 2022Article
- Review
- High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review.Bioengineering (Basel, Switzerland) · 2021Review
- Quantitative MRI T2 Mapping is Able to Assess Tissue Quality After Reparative and Regenerative Treatments of Osteochondral Lesions of the Talus.Journal of magnetic resonance imaging : JMRI · 2021Observational
- Cartilage Quality (dGEMRIC Index) Following Knee Joint Distraction or High Tibial Osteotomy.Cartilage · 2020Article
- Functional MRI for evaluation of hyaline cartilage extracelullar matrix, a physiopathological-based approach.The British journal of radiology · 2019Review
- Cartilage repair surgery prevents progression of knee degeneration.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Observational
- [Update cartilage imaging of the small joints : Focus on high-field MRI].Der Radiologe · 2019Review
- Clinical and radiographical ten years long-term outcome of microfracture vs. autologous chondrocyte implantation: a matched-pair analysis.International orthopaedics · 2019Article
- Article
- Quantitative Arthroscopic Assessment of Articular Cartilage Quality by Means of Cartilage Electromechanical Properties.Arthroscopy techniques · 2018Article
- [Advanced cartilage imaging for detection of cartilage injuries and osteochondral lesions].Der Radiologe · 2018Review
- Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures.Stem cells international · 2018Review
- Magnetic Resonance Imaging Score and Classification System (AMADEUS) for Assessment of Preoperative Cartilage Defect Severity.Cartilage · 2017Article
- T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis.World journal of orthopedics · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundNew quantitative magnetic resonance imaging (MRI) techniques are increasingly applied as outcome measures after cartilage repair.
objectiveTo review the current literature on the use of quantitative MRI biomarkers for evaluation of cartilage repair at the knee and ankle.
methodsUsing PubMed literature research, studies on biochemical, quantitative MR imaging of cartilage repair were identified and reviewed.
resultsQuantitative MR biomarkers detect early degeneration of articular cartilage, mainly represented by an increasing water content, collagen disruption, and proteoglycan loss. Recently, feasibility of biochemical MR imaging of cartilage repair tissue and surrounding cartilage was demonstrated. Ultrastructural properties of the tissue after different repair procedures resulted in differences in imaging characteristics. T2 mapping, T1rho mapping, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), and diffusion weighted imaging (DWI) are applicable on most clinical 1.5 T and 3 T MR scanners. Currently, a standard of reference is difficult to define and knowledge is limited concerning correlation of clinical and MR findings. The lack of histological correlations complicates the identification of the exact tissue composition.
conclusionsA multimodal approach combining several quantitative MRI techniques in addition to morphological and clinical evaluation might be promising. Further investigations are required to demonstrate the potential for outcome evaluation after cartilage repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.