Trial reportBioMed research international2014
Serum C-reactive protein and procalcitonin kinetics in patients undergoing elective total hip arthroplasty.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Inflammatory blood parameters as prognostic factors for implant-associated infection after primary total hip or knee arthroplasty: a systematic review.BMC musculoskeletal disorders · 2023Pooled it
- Multimodal perioperative care plus immunonutrition versus traditional care in total hip arthroplasty: a randomized pilot study.Nutrition journal · 2016Trial
- Risk factors for revisions in patients following total hip arthroplasty and hemiarthroplasty due to femoral neck fractures.International orthopaedics · 2026Article
- The Impact of Preoperative Inflammatory Activity in Patients with Ankylosing Spondylitis on Postoperative Joint Function: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Improved outcomes with perioperative dietitian-led interventions in patients undergoing total joint arthroplasty: A systematic review.Journal of orthopaedics · 2024Review
- Sex differences in inflammatory parameters after shoulder arthroplasty and blood loss.Frontiers in surgery · 2024Article
- Dynamics of C-reactive protein level after orthopedic surgeries.Journal of orthopaedics · 2024Article
- What Is the Normal Trajectory of C-Reactive Protein, Erythrocyte Sedimentation Rate, Plasma Fibrinogen and D-Dimer after Two-Stage Exchange for Periprosthetic Joint Infection?Orthopaedic surgery · 2022Article
- The Expanding Role of Biomarkers in Diagnosing Infection in Total Joint Arthroplasty: A Review of Current Literature.The archives of bone and joint surgery · 2021Review
- Metabolic Shock in Elderly Pertrochanteric or Intertrochanteric Surgery. Comparison of Three Surgical Methods. Is there a Much Safer?Romanian journal of anaesthesia and intensive care · 2020Article
- Postoperative Trends of Serum C-Reactive Protein Levels after Primary Shoulder Arthroplasty-Normal Trajectory and Influencing Factors.Journal of clinical medicine · 2020Article
- Comparing the use of preformed vs hand-made antibiotic spacer cement in two stages revision of hip periprosthetic infection.Journal of clinical orthopaedics and trauma · 2020Article
- Objectively measured early physical activity after total hip or knee arthroplasty.Journal of clinical monitoring and computing · 2019Article
- Different Kinetics of Perioperative CRP after Hip Arthroplasty for Elderly Femoral Neck Fracture with Elevated Preoperative CRP.BioMed research international · 2018Article
- [Safety evaluation of secondary conversion from external fixation to internal fixation for open tibia fractures].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Article
- Use of Common Inflammatory Markers in the Long-Term Screening of Total Hip Arthroprosthesis Infections: Our Experience.Advances in orthopedics · 2017Article
- A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood.EBioMedicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe sensitivity and the specificity of different methods to detect periprosthetic infection have been questioned. The current study aimed to investigate the kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in patients undergoing uncomplicated elective total hip arthroplasty (THA), to provide a better interpretation of their levels in noninfectious inflammatory reaction.
methodsA total of 51 patients were included. Serum CRP and PCT concentrations were obtained before surgery, on the 1st, 3rd, and 7th postoperative days and after discharge on the 14th and 30th days and at 2 years.
resultsBoth markers were confirmed to increase after surgery. The serum CRP showed a marked increase on the 3rd postoperative day while the peak of serum PCT was earlier, even if much lower, on the first day. Then, they declined slowly approaching the baseline values by the second postoperative week. PCT mean values never exceed concentrations typically related to bacterial infections.
conclusionsCRP is very sensitive to inflammation. It could be the routine screening test in the follow-up of THA orthopaedic patients, but it should be complemented by PCT when there is the clinical suspicion of periprosthetic infection.
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