Evidence map›Paper›PMID 24877110›Full record

Trial reportBioMed research international2014

Virulence factors associated with pediatric shigellosis in Brazilian Amazon.

Carolinie Batista Nobre da Cruz, Maria Carolina Scheffer de Souza, Paula Taquita Serra, Ivanildes Santos, Antonio Balieiro, Fabio Alessandro Pieri, Paulo Afonso Nogueira, Patrícia Puccinelli Orlandi

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 64 citations in OpenAlex.

  1. High pathogenic potential of Shigella flexneri strains descending from a common ancestor isolated over 34 years in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  2. Article
  3. Characteristics of PathogenicTropical medicine and infectious disease · 2024
    Article
  4. Article
  5. Article
  6. Molecular Mechanisms ofInternational journal of molecular sciences · 2023
    Review
  7. Antimicrobial Susceptibility Patterns ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Article
  8. Occurrence ofPathogens (Basel, Switzerland) · 2022
    Article
  9. Characterization of DiarreaghenicAntibiotics (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A high number of multidrug-resistant and predominant genetically related cluster of Shigella flexneri strains isolated over 34 years in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Existence of virulence genes in clinicalAnnals of translational medicine · 2019
    Article
  19. Virulence gene profiles ofPathogens and global health · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Carolinie Batista Nobre da CruzInstituto Leônidas e Maria Deane-Fiocruz Amazônia, Rua Terezina 476, Adrianópolis, 69.057-070 Manaus, AM, Brazil.
Maria Carolina Scheffer de SouzaPrograma de Pós Graduação em Imunologia Básica e Aplicada (PPGBA-UFAM), Avenida General Rodrigo Octávio 6200, Coroado I, 69.077-000 Manaus, AM, Brazil.
Paula Taquita SerraPrograma de Pós Graduação em Imunologia Básica e Aplicada (PPGBA-UFAM), Avenida General Rodrigo Octávio 6200, Coroado I, 69.077-000 Manaus, AM, Brazil.
Ivanildes SantosInstituto Leônidas e Maria Deane-Fiocruz Amazônia, Rua Terezina 476, Adrianópolis, 69.057-070 Manaus, AM, Brazil.
Antonio BalieiroInstituto Leônidas e Maria Deane-Fiocruz Amazônia, Rua Terezina 476, Adrianópolis, 69.057-070 Manaus, AM, Brazil.
Fabio Alessandro PieriDepartamento de Ciências Básicas da Saúde, Universidade Federal de Juiz de Fora, Câmpus Governador Valadares, Rua Israel Pinheiro 2000, Bairro Universitário, 35010177 Governador Valadares, MG, Brazil.
Paulo Afonso NogueiraInstituto Leônidas e Maria Deane-Fiocruz Amazônia, Rua Terezina 476, Adrianópolis, 69.057-070 Manaus, AM, Brazil.
Patrícia Puccinelli OrlandiInstituto Leônidas e Maria Deane-Fiocruz Amazônia, Rua Terezina 476, Adrianópolis, 69.057-070 Manaus, AM, Brazil.
Universidade Federal do Amazonas · BRUniversidade Federal de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shigellosis is a global human health problem and the incidence is highest among children. In the present work, main Shigella virulence genes was examined by PCR and compared to symptoms of pediatric shigellosis. Thirty Shigella isolates were identified from an etiologic study at which 1,339 children ranging 0-10 years old were enrolled. S. flexneri was the most frequent species reaching 60.0% of isolates, 22.2% were S. sonnei, and 6.6% were both S. dysenteriae and S. boydii. All Shigella infected children had diarrhea, but not all were accompanied by others symptoms of bacillary dysentery. Among major virulence genes, the PCR typing revealed ipaBCD was present in all isolates, followed by IpaH7.8, set-1A, set-1B, sen/ospD3, virF, and invE. The pathogenic potential of the ShET-1B subunit was observed in relation to dehydration (P < 0.001) and ShET-2 related to the intestinal injury (P = 0.033) evidenced by the presence of bloody diarrhea. Our results show associations among symptoms of shigellosis and virulence genes of clinical isolates of Shigella spp.

Indexed as

ShigellaAnimalsBrazilChildChild, PreschoolDysentery, BacillaryFemaleGenotyping TechniquesHumansInfantInfant, NewbornMaleRetrospective StudiesVirulence FactorsVirulence Factors

Identifiers

PMID24877110
PMCPMC4020526
OpenAlexW2042057505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.