ArticleBioMed research international2014
New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- How Many Blastocysts Are Needed for PGT-A to Benefit RPL Patients? A 7-Year Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Non-invasive preimplantation genetic testing for aneuploidy using cell-free DNA in blastocyst culture medium.Journal of assisted reproduction and genetics · 2025Article
- Non-Invasive Preimplantation Genetic Testing.Genes · 2025Review
- Preimplantation genetic testing in the current era, a review.Archives of gynecology and obstetrics · 2024Review
- Association of embryo aneuploidy and sperm DNA damage in unexplained recurrent implantation failure patients under NGS-based PGT-A cycles.Archives of gynecology and obstetrics · 2023Article
- Which type of chromosomal mosaicism is compatible for embryo transfer: a systematical review and meta-analysis.Archives of gynecology and obstetrics · 2022Review
- Article
- The impact of preimplantation genetic testing for aneuploidies (PGT-A) on clinical outcomes in high risk patients.Journal of assisted reproduction and genetics · 2022Article
- Results of Preimplantation Genetic Testing for Aneuploidy (PGT-A) in a Cohort of 319 Embryos: Experience in a Fertility Clinic in Colombia.JBRA assisted reproduction · 2022Observational
- Article
- Optimized NGS Approach for Detection of Aneuploidies and Mosaicism in PGT-A and Imbalances in PGT-SR.Genes · 2020Article
- Preimplantation Genetic Testing: Where We Are Today.International journal of molecular sciences · 2020Review
- Combination of QF-PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage.Molecular genetics & genomic medicine · 2019Article
- Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR).Journal of assisted reproduction and genetics · 2019Article
- Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization.Molecular cytogenetics · 2017Article
- Are there optimal numbers of oocytes, spermatozoa and embryos in assisted reproduction?JBRA assisted reproduction · 2016Review
- Confirmation rates of array-CGH in day-3 embryo and blastocyst biopsies for preimplantation genetic screening.Journal of assisted reproduction and genetics · 2016Article
- Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.Nature communications · 2015Article
- Role of Non-invasive Preimplantation Genetic Testing-Aneuploidy Using Spent Culture Media and its Concordance with Trophectoderm Biopsy: A Proof of Concept and Validation Study.Journal of human reproductive sciencesArticle
- EnhancingGynecology and minimally invasive therapyArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the usefulness of comprehensive chromosome screening (CCS) using array comparative genomic hybridization (aCGH). The study included 1420 CCS cycles for recurrent miscarriage (n = 203); repetitive implantation failure (n = 188); severe male factor (n = 116); previous trisomic pregnancy (n = 33); and advanced maternal age (n = 880). CCS was performed in cycles with fresh oocytes and embryos (n = 774); mixed cycles with fresh and vitrified oocytes (n = 320); mixed cycles with fresh and vitrified day-2 embryos (n = 235); and mixed cycles with fresh and vitrified day-3 embryos (n = 91). Day-3 embryo biopsy was performed and analyzed by aCGH followed by day-5 embryo transfer. Consistent implantation (range: 40.5-54.2%) and pregnancy rates per transfer (range: 46.0-62.9%) were obtained for all the indications and independently of the origin of the oocytes or embryos. However, a lower delivery rate per cycle was achieved in women aged over 40 years (18.1%) due to the higher percentage of aneuploid embryos (85.3%) and lower number of cycles with at least one euploid embryo available per transfer (40.3%). We concluded that aneuploidy is one of the major factors which affect embryo implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.