ReviewBioMed research international2014
The role of physical exercise in inflammatory bowel disease.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity.World journal of gastroenterology · 2025Pooled it
- Systematic Review: The Impact and Importance of Body Composition in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2022Pooled it
- Pooled it
- Role of environmental factors in the pathogenesis of Crohn's disease: a critical review.International journal of colorectal disease · 2019Pooled it
- Physical activity and sedentary levels in children with juvenile idiopathic arthritis and inflammatory bowel disease. A systematic review and meta-analysis.Pediatric research · 2019Pooled it
- Trial
- High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial.BMC gastroenterology · 2019Trial
- Trial
- Effect of the soft-tissue techniques in the quality of life in patients with Crohn's disease: A randomized controlled trial.Medicine · 2018Trial
- Review
- Mesenteric adipose tissue: from protective gatekeeper to driver of inflammatory bowel disease.Immunometabolism (Cobham, Surrey) · 2026Review
- Accelerometer-derived "weekend warrior" and regular physical activity on long-term risk of irritable bowel syndrome and subsequent depression: a large-scale prospective cohort study.Frontiers in public health · 2026Article
- Article
- Association between physical activity and inflammatory bowel disease: a prospective cohort study.Frontiers in public health · 2026Article
- Physical activity, sedentary behavior and risk of inflammatory bowel disease: a prospective cohort study in the UK Biobank.BMC public health · 2025Article
- The complex relationship between physical activity and fatigue with socioeconomic status, and mental health factors in individuals with inflammatory bowel disease.Journal of Crohn's & colitis · 2025Article
- Physical Activity and Education in the Care of IBD: The Role of the Physiotherapist-A Narrative Review.Journal of clinical medicine · 2025Review
- Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease.World journal of gastroenterology · 2025Review
- Gut, bone, and muscle: the triad of osteosarcopenia in inflammatory bowel disease.Intestinal research · 2025Review
- Environmental risk factors of inflammatory bowel disease: toward a strategy of preventative health.Journal of Crohn's & colitis · 2025Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reviewed and analyzed the relationship between physical exercise and inflammatory bowel disease (IBD) which covers a group of chronic, relapsing, and remitting intestinal disorders including Crohn's disease (CD) and ulcerative colitis. The etiology of IBD likely involves a combination of genetic predisposition and environmental risk factors. Physical training has been suggested to be protective against the onset of IBD, but there are inconsistencies in the findings of the published literature. Hypertrophy of the mesenteric white adipose tissue (mWAT) is recognized as a characteristic feature of CD, but its importance for the perpetuation of onset of this intestinal disease is unknown. Adipocytes synthesize proinflammatory and anti-inflammatory cytokines. Hypertrophy of mWAT could play a role as a barrier to the inflammatory process, but recent data suggest that deregulation of adipokine secretion is involved in the pathogenesis of CD. Adipocytokines and macrophage mediators perpetuate the intestinal inflammatory process, leading to mucosal ulcerations along the mesenteric border, a typical feature of CD. Contracting skeletal muscles release biologically active myokines, known to exert the direct anti-inflammatory effects, and inhibit the release of proinflammatory mediators from visceral fat. Further research is required to confirm these observations and establish exercise regimes for IBD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.