ArticleBioMed research international2014
CCAAT/enhancer-binding protein α is a crucial regulator of human fat mass and obesity associated gene transcription and expression.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
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- Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2023Article
- Identification and Functional Analysis ofInternational journal of molecular sciences · 2023Article
- M6A RNA Methylation-Based Epitranscriptomic Modifications in Plasticity-Related Genes via miR-124-C/EBPα-FTO-Transcriptional Axis in the Hippocampus of Learned Helplessness Rats.The international journal of neuropsychopharmacology · 2022Article
- The Novel Role of PGC1α in Bone Metabolism.International journal of molecular sciences · 2021Review
- ACOX1, regulated by C/EBPα and miR-25-3p, promotes bovine preadipocyte adipogenesis.Journal of molecular endocrinology · 2021Article
- NAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds.Scientific reports · 2020Article
- Large-scale transcriptome analysis identified RNA methylation regulators as novel prognostic signatures for lung adenocarcinoma.Annals of translational medicine · 2020Article
- Fluorometric determination of the CCAAT/enhancer binding protein alpha by using gold nanoparticles and a labeled protein-binding DNA.Mikrochimica acta · 2019Article
- Article
- Nuclear respiratory factor 2 induces SIRT3 expression.Aging cell · 2015Article
- Role of FTO in Adipocyte Development and Function: Recent Insights.International journal of endocrinology · 2015Review
- Green tea extracts reduce adipogenesis by decreasing expression of transcription factors C/EBPα and PPARγ.International journal of clinical and experimental medicine · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several susceptibility loci have been reported associated with obesity and T2DM in GWAS. Fat mass and obesity associated gene (FTO) is the first gene associated with body mass index (BMI) and risk for diabetes in diverse patient populations. FTO is highly expressed in the brain and pancreas, and is involved in regulating dietary intake and energy expenditure. While much is known about the epigenetic mutations contributing to obesity and T2DM, less is certain with the expression regulation of FTO gene. In this study, a highly conserved canonical C/EBP α binding site was located around position -45~-54 bp relative to the human FTO gene transcriptional start site. Site-directed mutagenesis of the putative C/EBP α binding sites decreased FTO promoter activity. Overexpression and RNAi studies also indicated that C/EBP α was required for the expression of FTO. Chromatin immunoprecipitation (ChIP) experiment was carried out and the result shows direct binding of C/EBP α to the putative binding regions in the FTO promoter. Collectively, our data suggest that C/EBP α may act as a positive regulator binding to FTO promoter and consequently, activates the gene transcription.
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