ArticleBioMed research international2014
Rural residents in China are at increased risk of exposure to tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 26 citations in OpenAlex.
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- Aetiologies of bacterial tick-borne febrile illnesses in humans in Africa: diagnostic limitations and the need for improvement.Frontiers in medicine · 2024Review
- Prevalence and genetic diversity ofFrontiers in veterinary science · 2024Article
- Assessment of Tick-Borne Diseases in Hainan Province, China.China CDC weekly · 2023Review
- Zoonotic pathogens identified in rodents and shrews from four provinces, China, 2015-2022.Epidemiology and infection · 2023Article
- Molecular Detection of Tick-Borne Bacterial and Protozoan Pathogens inPathogens (Basel, Switzerland) · 2023Article
- Molecular Detection ofMicroorganisms · 2022Article
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- Molecular epidemiology of bovine anaplasmosis in Khyber Pakhtunkhwa, Pakistan.Tropical animal health and production · 2018Article
- Prevalence and genetic variability of Anaplasma phagocytophilum in wild rodents from the Italian alps.Parasites & vectors · 2017Article
- Anaplasma spp. in dogs and owners in north-western Morocco.Parasites & vectors · 2017Article
- Prevalence of antibodies against Ehrlichia spp. and Orientia tsutsugamushi in small mammals around harbors in Taiwan.Parasites & vectors · 2016Article
- Article
- Anaplasma marginale and Anaplasma phagocytophilum: Rickettsiales pathogens of veterinary and public health significance.Parasitology research · 2015Review
- Prevalence and Genotyping of Cryptosporidium Infection in Pet Parrots in North China.BioMed research international · 2015Article
- Opening the black box of Anaplasma phagocytophilum diversity: current situation and future perspectives.Frontiers in cellular and infection microbiology · 2015Review
- First report of hepatitis E virus infection in sika deer in China.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
31 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As emerging tick born rickettsial diseases caused by A. phagocytophilum and E. chaffeensis, anaplasmosis and ehrlichiosis have become a serious threat to human and animal health throughout the world. In particular, in China, an unusual transmission of nosocomial cases of human granulocytic anaplasmosis occurred in Anhui Province in 2006 and more recent coinfection case of A. phagocytophilum and E. chaffeensis was documented in Shandong Province. Although the seroprevalence of human granulocytic anaplasmosis (former human granulocytic ehrlichiosis, HGE) has been documented in several studies, these data existed on local investigations, and also little data was reported on the seroprevalence of human monocytic ehrlichiosis (HME) in China. In this cross-sectional epidemiological study, indirect immunofluorescence antibody assay (IFA) proposed by WHO was used to detect A. phagocytophilum and E. chaffeensis IgG antibodies for 7,322 serum samples from agrarian residents from 9 provinces/cities and 819 urban residents from 2 provinces. Our data showed that farmers were at substantially increased risk of exposure. However, even among urban residents, risk was considerable. Seroprevalence of HGA and HME occurred in diverse regions of the country and tended to be the highest in young adults. Many species of ticks were confirmed carrying A. phagocytophilum organisms in China while several kinds of domestic animals including dog, goats, sheep, cattle, horse, wild rabbit, and some small wild rodents were proposed to be the reservoir hosts of A. phagocytophilum. The broad distribution of vector and hosts of the A. phagocytophilum and E. chaffeensis, especially the relationship between the generalized susceptibility of vectors and reservoirs and the severity of the disease's clinical manifestations and the genetic variation of Chinese HGA isolates in China, is urgently needed to be further investigated.
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