ArticleJournal of exercise rehabilitation2014
Swimming exercise ameliorates multiple sclerosis-induced impairment of short-term memory by suppressing apoptosis in the hippocampus of rats.
Article in Journal of exercise rehabilitation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Exploring the underlying mechanisms of exercise as therapy for multiple sclerosis: insights from preclinical studies.Frontiers in cellular neuroscience · 2024Review
- Dimorphic evaluation of hippocampal changes in rat model of demyelination: A comparative functional, morphometric, and histological study.Brain and behavior · 2022Article
- Aerobic training improves blood-brain barrier and neuronal apoptosis in experimental autoimmune encephalomyelitis.Iranian journal of basic medical sciences · 2022Article
- Attenuated Renal and Hepatic Cells Apoptosis Following Swimming Exercise Supplemented with Garlic Extract in Old Rats.Clinical interventions in aging · 2020Article
- Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer's.Metabolic brain disease · 2019Review
- Modifiable Risk Factors for Alzheimer's Disease.Frontiers in aging neuroscience · 2019Article
- Treadmill exercise ameliorates symptoms of Alzheimer disease through suppressing microglial activation-induced apoptosis in rats.Journal of exercise rehabilitation · 2016Article
- Ovarian and uterine alterations following forced swimming: An immunohistochemical study.International journal of reproductive biomedicine · 2016Article
- Aqueous extract of Cordyceps alleviates cerebral ischemia-induced short-term memory impairment in gerbils.Journal of exercise rehabilitation · 2016Article
- Treadmill exercise improves short-term memory by enhancing hippocampal cell proliferation in quinolinic acid-induced Huntington's disease rats.Journal of exercise rehabilitation · 2015Article
- Influence of mild traumatic brain injury during pediatric stage on short-term memory and hippocampal apoptosis in adult rats.Journal of exercise rehabilitation · 2014Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis is one of the autoimmune diseases in the central nervous system. Multiple sclerosis occurs through multiple mechanisms, and it is also mediated in part by an apoptotic mechanism. Swimming exercise has been recommended for the prevention and treatment of chronic diseases. In the present study, we investigated the effects of swimming exercise on short-term memory in relation with apoptotic neuronal cell death in the hippocampus following induction of multiple sclerosis. For this study, step-down avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, immunohistochemistry for caspase-3 were performed. The animal model of multiple sclerosis was made by bilateral intracerebral ventricle injection of ethidium bromide. The rats in the swimming exercise groups were forced to swim for 30 min once daily for 14 consecutive days, starting 3 days after induction of multiple sclerosis. In the present results, short-term memory was deteriorated in the multiple sclerosis-induced rats. The number of TUNEL-positive and caspase-3-positive cells in the hippocampal dentate gyrus was increased in the multiple sclerosis-induced rats. Swimming exercise alleviated multiple sclerosis-induced short-term memory impairment by suppressing apoptotic neuronal cell death in the hippocampus. These effects of swimming exercise may aid symptom relief in the incurable neurodegenerative diseases.
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