ArticleBiomedical optics express2014
Intravital imaging of mouse colonic adenoma using MMP-based molecular probes with multi-channel fluorescence endoscopy.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- In Vivo Microendoscopy in the Near-Infrared II Window.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Infrared thermal modulation endoscopy for label-free tumor detection.Scientific reports · 2024Article
- Confocal Endomicroscopy Monitoring of Tumor Formation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Intravital longitudinal cellular visualization of oral mucosa in a murine model based on rotatory side-view confocal endomicroscopy.Biomedical optics express · 2022Article
- Enhancement of signal-to-noise ratio for fluorescence endoscope image based on fast digital lock-in algorithm.Royal Society open science · 2021Article
- Method for Acute Intravital Imaging of the Large Intestine in Live Mice.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Multicolor fluorescence imaging using a single RGB-IR CMOS sensor for cancer detection with smURFP-labeled probiotics.Biomedical optics express · 2020Article
- Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model.Scientific reports · 2018Article
- Active thermodynamic contrast imaging for label-free tumor detection in a murine xenograft tumor model.Biomedical optics express · 2017Article
- Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model.Biomedical optics express · 2017Article
- A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer.Molecular imaging and biology · 2016Article
- Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression.F1000Research · 2016Review
- In vivo longitudinal cellular imaging of small intestine by side-view endomicroscopy.Biomedical optics express · 2015Article
- Confocal laser endomicroscopy to monitor the colonic mucosa of mice.Journal of immunological methods · 2015Article
- Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology.Theranostics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravital imaging has provided molecular, cellular and anatomical insight into the study of tumor. Early detection and treatment of gastrointestinal (GI) diseases can be enhanced with specific molecular markers and endoscopic imaging modalities. We present a wide-field multi-channel fluorescence endoscope to screen GI tract for colon cancer using multiple molecular probes targeting matrix metalloproteinases (MMP) conjugated with quantum dots (QD) in AOM/DSS mouse model. MMP9 and MMP14 antibody (Ab)-QD conjugates demonstrate specific binding to colonic adenoma. The average target-to-background (T/B) ratios are 2.10 ± 0.28 and 1.78 ± 0.18 for MMP14 Ab-QD and MMP9 Ab-QD, respectively. The overlap between the two molecular probes is 67.7 ± 8.4%. The presence of false negative indicates that even more number of targeting could increase the sensitivity of overall detection given heterogeneous molecular expression in tumors. Our approach indicates potential for the screening of small or flat lesions that are precancerous.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.