ArticleBiomedical optics express2014
Hybrid FMT-MRI applied to in vivo atherosclerosis imaging.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Reconstruction of fluorophore absorption and fluorescence lifetime using early photon mesoscopic fluorescence molecular tomography: a phantom study.Journal of biomedical optics · 2022Article
- Multi-branch attention prior based parameterized generative adversarial network for fast and accurate limited-projection reconstruction in fluorescence molecular tomography.Biomedical optics express · 2022Article
- Bioluminescence tomography reconstruction in conjunction with an organ probability map as an anatomical reference.Biomedical optics express · 2022Article
- Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics.Frontiers in medicine · 2022Review
- Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment.Pharmaceutics · 2019Review
- Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation.PloS one · 2019Article
- Bioluminescence tomography with structural information estimated via statistical mouse atlas registration.Biomedical optics express · 2018Article
- PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis.Current cardiology reports · 2018Review
- Region-based diffuse optical tomography with registered atlas:Biomedical optics express · 2016Article
- Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models.International journal of molecular sciences · 2016Review
- Advances in optical imaging for pharmacological studies.Frontiers in pharmacology · 2015Review
- Shape-parameterized diffuse optical tomography holds promise for sensitivity enhancement of fluorescence molecular tomography.Biomedical optics express · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combining Fluorescent Molecular Tomography (FMT) with anatomical imaging, e.g. MRI facilitates interpreting functional information. Furthermore, using a heterogeneous model for light propagation has been shown in simulations to be superior to homogeneous modeling to quantify fluorescence. Here, we present a combined FMT-MRI system and apply it to heart and aorta molecular imaging, a challenging area due to strong tissue heterogeneity and the presence of air-voids due to lungs. First investigating performance in a phantom and mouse corpse, the MRI-enabled heterogeneous models resulted in an improved quantification of fluorescence reconstructions. The system was then used in mice for in vivo atherosclerosis molecular imaging. Results show that, when using the heterogeneous model, reconstructions were in agreement with the ex vivo measurements. Therefore, the proposed system might serve as a powerful imaging tool for atherosclerosis in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.