Evidence map›Paper›PMID 24877000›Full record

ArticleBiomedical optics express2014

Photo-induced processes in collagen-hypericin system revealed by fluorescence spectroscopy and multiphoton microscopy.

V Hovhannisyan, H W Guo, A Hovhannisyan, V Ghukasyan, T Buryakina, Y F Chen, C Y Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Photodynamic Efficiency: From Molecular Photochemistry to Cell Death.International journal of molecular sciences · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

V HovhannisyanDepartment of Physics, National Taiwan University, Taipei106, Taiwan.
H W GuoDepartment of Physics, National Taiwan University, Taipei106, Taiwan.
A HovhannisyanMultimedia &Programming, European Regional Education Academy, Yerevan, Armenia.
V GhukasyanNeuroscience Center, University of North Carolina at Chapel Hill, NC USA.
T BuryakinaDepartment of Physics, National Taiwan University, Taipei106, Taiwan.
Y F ChenDepartment of Physics, National Taiwan University, Taipei106, Taiwan ; yfchen@phys.ntu.edu.tw.
C Y DongDepartment of Physics, National Taiwan University, Taipei106, Taiwan ; Center for Quantum Science and Engineering, National Taiwan University, Taipei 106, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagen is the main structural protein and the key determinant of mechanical and functional properties of tissues and organs. Proper balance between synthesis and degradation of collagen molecules is critical for maintaining normal physiological functions. In addition, collagen influences tumor development and drug delivery, which makes it a potential cancer therapy target. Using second harmonic generation, two-photon excited fluorescence microscopy, and spectrofluorimetry, we show that the natural pigment hypericin induces photosensitized destruction of collagen-based tissues. We demonstrate that hypericin-mediated processes in collagen fibers are irreversible and may be used for the treatment of cancer and collagen-related disorders.

Indexed as

(170.3880) Medical and biological imaging(180.4315) Nonlinear microscopy(190.1900) Diagnostic applications of nonlinear optics

Identifiers

PMID24877000
PMCPMC4026910

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.