Trial reportOxidative medicine and cellular longevity2014
Lipid and protein oxidation in newborn infants after lutein administration.
Trial report in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Antioxidant Activity of Oral Lutein in Preterm and Term Newborn
Evaluation of the Antioxidant Activity of Lutein/Zeaxanthin Early Administered to Premature Newborns
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Lutein and zeaxanthin for reducing morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Longitudinal analysis of carotenoid content in preterm human milk.European journal of pediatrics · 2024Article
- Lutein Production and Extraction from Microalgae: Recent Insights and Bioactive Potential.International journal of molecular sciences · 2024Review
- Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes.F1000Research · 2024Review
- Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Lutein and Zeaxanthin Intake during Pregnancy and Visual Function in Offspring at 11-12 Years of Age.Nutrients · 2022Article
- Review
- Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study.Nutrients · 2020Article
- Nutritional Gaps and Supplementation in the First 1000 Days.Nutrients · 2019Review
- Protective Effect of Breastfeeding on the Adverse Health Effects Induced by Air Pollution: Current Evidence and Possible Mechanisms.International journal of environmental research and public health · 2019Review
- Carotenoids and Markers of Oxidative Stress in Human Observational Studies and Intervention Trials: Implications for Chronic Diseases.Antioxidants (Basel, Switzerland) · 2019Review
- Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to CuJournal of nutrition and metabolism · 2019Article
- Intrinsic and Extrinsic Factors Impacting Absorption, Metabolism, and Health Effects of Dietary Carotenoids.Advances in nutrition (Bethesda, Md.) · 2018Review
- Lutein, zeaxanthin and mammalian development: Metabolism, functions and implications for health.Archives of biochemistry and biophysics · 2018Review
- The Free Radical Diseases of Prematurity: From Cellular Mechanisms to Bedside.Oxidative medicine and cellular longevity · 2018Review
- Health Effects of Carotenoids during Pregnancy and Lactation.Nutrients · 2017Review
- Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models.Advances in nutrition (Bethesda, Md.) · 2017Review
- Effect of Carotenoid Supplemented Formula on Carotenoid Bioaccumulation in Tissues of Infant Rhesus Macaques: A Pilot Study Focused on Lutein.Nutrients · 2017Article
- Lutein and Neurodevelopment in Preterm Infants.Frontiers in neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo test the hypothesis that neonatal supplementation with lutein in the first hours of life reduces neonatal oxidative stress (OS) in the immediate postpartum period.
methodsA randomized controlled, double-blinded clinical trial was conducted among 150 newborns divided into control group, not supplemented (n = 47), and test group, supplemented with lutein on the first day postpartum (n = 103). Blood Samples were collected at birth from cord and at 48 hrs postpartum while routine neonatal metabolic screenings were taking place. Total hydroperoxide (TH), advanced oxidation protein products (AOPP), and biological antioxidant potential (BAP) were measured by spectrophotometry and data were analyzed by Wilcoxon rank sum test and by multivariate logistic regression analysis.
resultsBefore lutein supplementation, the mean blood concentrations of AOPP, TH, and BAP were 36.10 umol/L, 156.75 mmol/H2O2, and 2361.04 umol/L in the test group. After lutein supplementation, significantly higher BAP increment (0.17 ± 0.22 versus 0.06 versus ± 0.46) and lower TH increment (0.46 ± 0.54 versus 0.34 ± 0.52) were observed in the test group compared to controls.
conclusionNeonatal supplementation with lutein in the first hours of life increases BAP and reduces TH in supplemented babies compared to those untreated. The generation of free radical-induced damage at birth is reduced by lutein. This trial is registered with ClinicalTrials.gov NCT02068807.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.