ArticleOxidative medicine and cellular longevity2014
Effects of treating old rats with an aqueous Agaricus blazei extract on oxidative and functional parameters of the brain tissue and brain mitochondria.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms.Journal of fungi (Basel, Switzerland) · 2024Review
- Herbal/Natural Compounds Resist Hallmarks of Brain Aging: From Molecular Mechanisms to Therapeutic Strategies.Antioxidants (Basel, Switzerland) · 2023Review
- Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Strenuous swimming raises blood non-enzymatic antioxidant capacity in rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2022Article
- Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model.International journal of molecular sciences · 2020Article
- Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats.Antioxidants (Basel, Switzerland) · 2019Article
- Antigenotoxic Properties ofOxidative medicine and cellular longevity · 2017Article
- Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F fromFrontiers in pharmacology · 2017Article
- Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria.Malaria journal · 2015Article
- Effects of the continuous administration of an Agaricus blazei extract to rats on oxidative parameters of the brain and liver during aging.Molecules (Basel, Switzerland) · 2014Article
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6 authors.
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Abstract
Dysfunction of the mitochondrial respiratory chain and increased oxidative stress is a striking phenomenon in the brain of aged individuals. For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate these problems. In the present study the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state and on the functionality of mitochondria from the brain of old rats (21 months) were conducted. The extract was administered intragastrically during 21 days at doses of 200 mg/kg. The administration of the A. blazei extract was protective to the brain of old rats against oxidative stress by decreasing the lipid peroxidation levels and the reactive oxygen species content and by increasing the nonenzymic and enzymic antioxidant capacities. Administration of the A. blazei extract also increased the activity of several mitochondrial respiratory enzymes and, depending on the substrate, the mitochondrial coupled respiration.
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