ReviewWorld journal of gastroenterology2014
Aetiology and risk factors of ischaemic cholangiopathy after liver transplantation.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 111 citations in OpenAlex.
- Trial
- Cholangiocyte biology in primary sclerosing cholangitis and other cholangiopathies: pathogenesis, clinical insights, and experimental tools.Physiological reviews · 2026Review
- Lipoprotein X-Induced Hyperlipidemia Following Liver Transplantation in the Setting of Persistent Cholestasis and Antibody-Mediated Rejection.ACG case reports journal · 2025Article
- L-FABP as a Potential Biomolecular Marker of Liver Graft Injury.Journal of clinical medicine · 2025Article
- The Impact of Normothermic Machine Perfusion on Biliary Complications in Donation After Circulatory Death Donor Liver Transplantation.Transplantation direct · 2025Article
- Prolonged warm ischemia time in the recipient is associated with post-transplant biliary stricture following living-donor liver transplantation.Surgery today · 2024Article
- Comparative Analysis of Digestion Methods for Bile Proteomics: The Key to Unlocking Biliary Biomarker Potential.Analytical chemistry · 2024Article
- Modern-Day Practice of DCD Liver Transplantation: Controversies, Innovations, and Future Directions.Current gastroenterology reports · 2023Review
- Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers.Nature communications · 2023Article
- Transplant Hepatic Artery Rupture.Seminars in interventional radiology · 2023Review
- Application of cholecystic duct plasty in the prevention of biliary complications following orthotopic liver transplantation.Frontiers in surgery · 2023Article
- Ultrastructural changes in porcine liver sinusoidal endothelial cells of machine perfused liver donated after cardiac death.World journal of gastroenterology · 2022Article
- Sense and Sensibilities of Organ Perfusion as a Kidney and Liver Viability Assessment Platform.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
- Modern imaging of cholangitis.The British journal of radiology · 2021Review
- Biliary Strictures: Etiologies and Medical Management.Seminars in interventional radiology · 2021Review
- Article
- Biliary Strictures Are Associated With Both Early and Late Hepatic Artery Stenosis.Transplantation direct · 2021Article
- Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.PloS one · 2021Article
- A new heart for organ donation after circulatory death.BJA education · 2020Review
- Addressing organ shortages: progress in donation after circulatory death for liver transplantationCanadian journal of surgery. Journal canadien de chirurgie · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver transplantation (LT) is the best treatment for end-stage hepatic failure, with an excellent survival rates over the last decade. Biliary complications after LT pose a major challenge especially with the increasing number of procured organs after circulatory death. Ischaemic cholangiopathy (IC) is a set of disorders characterized by multiple diffuse strictures affecting the graft biliary system in the absence of hepatic artery thrombosis or stenosis. It commonly presents with cholestasis and cholangitis resulting in higher readmission rates, longer length of stay, repeated therapeutic interventions, and eventually re-transplantation with consequent effects on the patient's quality of life and increased health care costs. The pathogenesis of IC is unclear and exhibits a higher prevalence with prolonged ischaemia time, donation after circulatory death (DCD), rejection, and cytomegalovirus infection. The majority of IC occurs within 12 mo after LT. Prolonged warm ischaemic times predispose to a profound injury with a subsequently higher prevalence of IC. Biliary complications and IC rates are between 16% and 29% in DCD grafts compared to between 3% and 17% in donation after brain death (DBD) grafts. The majority of ischaemic biliary lesions occur within 30 d in DCD compared to 90 d in DBD grafts following transplantation. However, there are many other risk factors for IC that should be considered. The benefits of DCD in expanding the donor pool are hindered by the higher incidence of IC with increased rates of re-transplantation. Careful donor selection and procurement might help to optimize the utilization of DCD grafts.
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