ReviewWorld journal of gastroenterology2014
Transfusion and coagulation management in liver transplantation.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Investigating the role of artificial intelligence in predicting risk factors after liver transplantation: A systematic review.Canadian liver journal · 2026Pooled it
- Pooled it
- Trial
- Relationship between Stroke Volume Variation and Blood Transfusion during Liver Transplantation.International journal of medical sciences · 2016Trial
- Machine learning-based risk factors for acute-on-chronic liver failure in alcohol-associated liver disease.Annals of medicine · 2026Observational
- Thromboelastographic description of intraoperative coagulopathy in patients undergoing liver transplant surgery: A single-center observational study.World journal of transplantation · 2026Article
- Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study.Perioperative medicine (London, England) · 2026Article
- Prothrombin complex concentrate use in liver transplantation: an international survey of current practices.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Using a Graft Arrival Time Estimation Formula Decreases Operation Time in Transplantation From Deceased Donor.Journal of Korean medical science · 2025Article
- Ultra-massive fluid transfusion in adult liver transplant recipients: A single center observational study.PloS one · 2025Observational
- A Review of the Risk Factors and Approaches to Prevention of Post-Reperfusion Syndrome During Liver Transplantation.Organogenesis · 2024Review
- Viscoelastic Hemostatic Testing as a Diagnostic Tool for Hypercoagulability in Liver Transplantation: A Narrative Review.Journal of clinical medicine · 2024Review
- Factors Affecting Intraoperative Blood Transfusion Requirements during Living Donor Liver Transplantation.Journal of clinical medicine · 2024Article
- Predictive role of hepatic venous pressure gradient in bleeding events among patients with cirrhosis undergoing orthotopic liver transplantation.JHEP reports : innovation in hepatology · 2024 · on this mapArticle
- Analysis of the incidence and risk factors of blood transfusion in total knee revision: a retrospective nationwide inpatient sample database study.BMC musculoskeletal disorders · 2024Article
- Implementation of a Bleeding Management Algorithm in Liver Transplantation: A Pilot Study.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Article
- Thromboelastography-Guided Correction of Coagulopathy Before Tunneled Central Venous Access in Critically Ill Patients With Liver Disease: A Propensity Score-Matched Study.Critical care explorations · 2023Article
- Anesthetic Considerations for Patients With Mitral Stenosis Undergoing Orthotopic Liver Transplant.Cureus · 2023Article
- Prediction of New-Onset Diabetes Mellitus within 12 Months after Liver Transplantation-A Machine Learning Approach.Journal of clinical medicine · 2023Article
- Viscoelastic Management of Coagulopathy during the Perioperative Period of Liver Transplantation.Seminars in thrombosis and hemostasis · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is wide variation in the management of coagulation and blood transfusion practice in liver transplantation. The use of blood products intraoperatively is declining and transfusion free transplantations take place ever more frequently. Allogenic blood products have been shown to increase morbidity and mortality. Primary haemostasis, coagulation and fibrinolysis are altered by liver disease. This, combined with intraoperative disturbances of coagulation, increases the risk of bleeding. Meanwhile, the rebalancing of coagulation homeostasis can put patients at risk of hypercoagulability and thrombosis. The application of the principles of patient blood management to transplantation can reduce the risk of transfusion. This includes: preoperative recognition and treatment of anaemia, reduction of perioperative blood loss and the use of restrictive haemoglobin based transfusion triggers. The use of point of care coagulation monitoring using whole blood viscoelastic testing provides a picture of the complete coagulation process by which to guide and direct coagulation management. Pharmacological methods to reduce blood loss include the use of anti-fibrinolytic drugs to reduce fibrinolysis, and rarely, the use of recombinant factor VIIa. Factor concentrates are increasingly used; fibrinogen concentrates to improve clot strength and stability, and prothrombin complex concentrates to improve thrombin generation. Non-pharmacological methods to reduce blood loss include surgical utilisation of the piggyback technique and maintenance of a low central venous pressure. The use of intraoperative cell salvage and normovolaemic haemodilution reduces allogenic blood transfusion. Further research into methods of decreasing blood loss and alternatives to blood transfusion remains necessary to continue to improve outcomes after transplantation.
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