Evidence map›Paper›PMID 24876734›Full record

ReviewWorld journal of gastroenterology2014

Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer.

Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Munehiro Nakata, Wei Tang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Sialylation Inhibition Impairs Migration and Promotes Adhesion of GBM Cells.International journal of molecular sciences · 2025
    Article
  2. Article
  3. MUC1: Structure, Function, and Clinic Application in Epithelial Cancers.International journal of molecular sciences · 2021
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yoshinori InagakiYoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
Jianjun GaoYoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
Peipei SongYoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
Norihiro KokudoYoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
Munehiro NakataYoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
Wei TangYoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant expression of glycoconjugates occurs during malignant transformation of cancer cells. Overexpression of sialoglycoconjugates in particular may play an important role in the progression, i.e., invasion or metastasis, of cancer. Various types of sialoglycoconjugates have been investigated to clarify their biological significance and clinical utility in diagnosing and treating colorectal cancer. This review focuses specifically on expression of mucin (MUC) 1 and it suggests that MUC1 with the specific structure of a sialo-oligosaccharide has biological significance in determining the metastatic potential of colorectal cancer cells and clinicopathological utility in evaluating the effectiveness of treatments and the prognosis for patients with colorectal cancer. Further studies are expected to contribute to the expanded use of cancer-associated sialoglycoconjugates in cancer diagnosis and therapy.

Indexed as

Gene Expression Regulation, NeoplasticAntigens, Tumor-Associated, CarbohydrateCA-19-9 AntigenColorectal NeoplasmsDiagnostic ImagingGlycoconjugatesHumansMucin-1Neoplasm InvasivenessNeoplasm MetastasisOligosaccharidesPrognosisSialic AcidsSialyl Lewis X AntigenAntigens, Tumor-Associated, CarbohydrateCA-19-9 AntigenGlycoconjugatesMUC1 protein, humanMucin-1OligosaccharidesSialic Acidssialosyl-Tn antigenSialyl Lewis X AntigenColorectal cancerInvasionMetastasisMucin 1Sialic acidSialoglycoconjugates

Identifiers

PMID24876734
PMCPMC4033451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.