Evidence map›Paper›PMID 24876724›Full record

ReviewWorld journal of gastroenterology2014

Irritable bowel syndrome in children: pathogenesis, diagnosis and evidence-based treatment.

Bhupinder Kaur Sandhu, Siba Prosad Paul

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02613078 (Gut-Directed Hypnotherapy vs. Probiotics in Children and Adolescents With Irritable Bowel Syndrome and Functional Abdominal Pain - A Pilot Study), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02613078 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Gut-Directed Hypnotherapy vs. Probiotics in Children and Adolescents With Irritable Bowel Syndrome and Functional Abdominal Pain - A Pilot Study

TypeinterventionalSponsorUniversity Hospital TuebingenRan2016 to 2017Enrolled60ConditionsIrritable Bowel Syndrome, Functional Abdominal Pain SyndromeArmsGut-Directed Hypnotherapy, Nutritional Supplement, Self-Monitoring
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Article
  6. Review
  7. Article
  8. Review
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  10. The biopsychosocial model: Its use and abuse.Medicine, health care, and philosophy · 2023
    Article
  11. Article
  12. Review
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  15. Article
  16. Review
  17. Article
  18. Probiotics in Disease Prevention and Treatment.Journal of clinical pharmacology · 2018
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bhupinder Kaur SandhuBhupinder Kaur Sandhu, Siba Prosad Paul, Department of Pediatric Gastroenterology, Bristol Royal Hospital for Children, Bristol BS2 8BJ, United Kingdom.
Siba Prosad PaulBhupinder Kaur Sandhu, Siba Prosad Paul, Department of Pediatric Gastroenterology, Bristol Royal Hospital for Children, Bristol BS2 8BJ, United Kingdom.
Bristol Royal Hospital for Children · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is the commonest cause of recurrent abdominal pain (RAP) in children in both more developed and developing parts of the world. It is defined by the Rome III criteria for functional gastrointestinal disorders. It is characterized by abdominal pain that is improved by defecation and whose onset is associated with a change in stool form and or frequency and is not explained by structural or biochemical abnormalities. It is estimated that 10%-15% of older children and adolescents suffer from IBS. IBS can be considered to be a brain-gut disorder possibly due to complex interaction between environmental and hereditary factors. The diagnosis of IBS is made based on the Rome III criteria together with ruling out organic causes of RAP in children such as inflammatory bowel disease and celiac disease. Once the diagnosis of IBS is made, it is important to explain to the parents (and children) that there is no serious underlying disease. This reassurance may be effective treatment in a large number of cases. Lifestyle modifications, stress management, dietary interventions and probiotics may be beneficial in some cases. Although there is limited evidence for efficacy of pharmacological therapies such as antispasmodics and antidiarrheals; these have a role in severe cases. Biopsychosocial therapies have shown encouraging results in initial trials but are beset by limited availability. Further research is necessary to understand the pathophysiology and provide specific focused therapies.

Indexed as

Abdominal PainAdolescentAntidiarrhealsChildDrug TherapyEvidence-Based MedicineFemaleHumansIrritable Bowel SyndromeLife StyleMaleParasympatholyticsParentsProbioticsPsychotherapyRecurrenceAntidiarrhealsParasympatholyticsBiopsychosocial therapiesBrain-gut disorderChildrenIrritable bowel syndromeLifestyle modificationsRecurrent abdominal painRome III criteria

Identifiers

PMID24876724
PMCPMC4033441
OpenAlexW2148456915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.