ArticleJournal of diabetes science and technology2014
Vagus nerve stimulation and food intake: effect of body mass index.
Article in Journal of diabetes science and technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial.Scientific reports · 2016Trial
- The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026Review
- Vagus Nerve Suppression in Ischemic Stroke by Carotid Artery Occlusion: Implications for Metabolic Regulation, Cognitive Function, and Gut Microbiome in a Gerbil Model.International journal of molecular sciences · 2024Article
- Significant vomiting and weight loss in a pediatric epilepsy patient secondary to vagus nerve stimulation: A case report and review of the literature.Epilepsy & behavior reports · 2023Article
- Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin.Physiological reports · 2022Article
- Modulation of visual processing of food by transcutaneous vagus nerve stimulation (tVNS).Brain imaging and behavior · 2021Article
- Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety.Scientific reports · 2021Article
- Brain Stimulation to Modulate Food Intake and Eating Behavior.Current diabetes reports · 2019Review
- Gut Microbiome Modulation Based on Probiotic Application for Anti-Obesity: A Review on Efficacy and Validation.Microorganisms · 2019Review
- Effect of vagus nerve stimulation on blood glucose concentration in epilepsy patients - Importance of stimulation parameters.Physiological reports · 2019Article
- Anatomo-Physiologic Basis for Auricular Stimulation.Medical acupuncture · 2018Review
- Differential hemodynamic and respiratory responses to right and left cervical vagal nerve stimulation in rats.Physiological reports · 2017Article
- Desensitization of stimulation-induced weight loss: A secondary finding in a patient with vagal nerve stimulator for drug-resistant epilepsy.Epilepsy & behavior case reports · 2017Article
- Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation.Physiological reports · 2016Article
- Chronic Electrical Stimulation at Acupoints Reduces Body Weight and Improves Blood Glucose in Obese Rats via Autonomic Pathway.Obesity surgery · 2015Article
- Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity.NeuroImage. Clinical · 2015Review
- kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal research suggests that vagus nerve stimulation (VNS) is associated with weight loss and decreased appetite. Results from human studies are mixed; some suggest that VNS affects weight whereas others do not, and it is unclear how VNS affects eating behaviors. Baseline body mass index (BMI) and VNS device settings may moderate the effects of VNS on caloric intake. This study investigates the association among BMI, VNS device settings, and caloric intake of highly palatable foods during VNS on versus VNS off sessions in 16 adult patients (62.5% female; BMI mean = 29.11 ± 6.65) using VNS therapy for either epilepsy or depression. Participants attended 2 experimental sessions (VNS on versus off) where they were presented with 4 preferred snack foods totaling 1600 calories. At the start of the session, they either had their VNS devices turned off or left on. Caloric intake was calculated by weighing foods before and after each session. BMI category (overweight/obese and lean) was the between group factor in the analysis. After controlling for covariates, an interaction of condition and BMI category (P = .03) was found. There was an interaction of condition and device output current (P = .05) and a trend toward an interaction of condition and device on time (P = .07). Excess weight may impact how neurobiological signals from the vagus nerve affect appetite and eating. Future research is needed to further elucidate this relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.