Trial reportJournal of diabetes science and technology2014
An integrated multivariable artificial pancreas control system.
Trial report in Journal of diabetes science and technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 78 citations in OpenAlex.
- Prediction of Hypoglycemia During Aerobic Exercise in Adults With Type 1 Diabetes.Journal of diabetes science and technology · 2019Trial
- Lag Time Remains with Newer Real-Time Continuous Glucose Monitoring Technology During Aerobic Exercise in Adults Living with Type 1 Diabetes.Diabetes technology & therapeutics · 2019Trial
- Randomized Outpatient Trial of Single- and Dual-Hormone Closed-Loop Systems That Adapt to Exercise Using Wearable Sensors.Diabetes care · 2018Trial
- Mitigating Reductions in Glucose During Exercise on Closed-Loop Insulin Delivery: The Ex-Snacks Study.Diabetes technology & therapeutics · 2016Trial
- Randomized trial of a dual-hormone artificial pancreas with dosing adjustment during exercise compared with no adjustment and sensor-augmented pump therapy.Diabetes, obesity & metabolism · 2016Trial
- Hypoglycemia Detection and Carbohydrate Suggestion in an Artificial Pancreas.Journal of diabetes science and technology · 2016Trial
- Performance of continuous glucose monitoring-based meal detection algorithms in young healthy adults.Scientific reports · 2026Article
- Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems.Journal of diabetes science and technology · 2025Review
- The Type 1 Diabetes and EXercise Initiative: Predicting Hypoglycemia Risk During Exercise for Participants with Type 1 Diabetes Using Repeated Measures Random Forest.Diabetes technology & therapeutics · 2023Article
- Continuous glucose monitoring for automatic real-time assessment of eating events and nutrition: a scoping review.Frontiers in nutrition · 2023Article
- Precision medicine in type 1 diabetes.Diabetologia · 2022Review
- Integrating Multiple Inputs Into an Artificial Pancreas System: Narrative Literature Review.JMIR diabetes · 2022Review
- Intelligent automated drug administration and therapy: future of healthcare.Drug delivery and translational research · 2021Review
- Determining Physical Activity Characteristics from Wristband Data for Use in Automated Insulin Delivery Systems.IEEE sensors journal · 2020Article
- Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes.Endocrine reviews · 2019Review
- Enhanced Accuracy of Continuous Glucose Monitoring during Exercise through Physical Activity Tracking Integration.Sensors (Basel, Switzerland) · 2019Article
- Automated Insulin Delivery Algorithms.Diabetes spectrum : a publication of the American Diabetes Association · 2019Article
- Plasma-Insulin-Cognizant Adaptive Model Predictive Control for Artificial Pancreas Systems.Journal of process control · 2019Article
- Multi-Model Sensor Fault Detection and Data Reconciliation: A Case Study with Glucose Concentration Sensors for Diabetes.AIChE journal. American Institute of Chemical Engineers · 2019Article
- Accuracy of Wrist-Worn Activity Monitors During Common Daily Physical Activities and Types of Structured Exercise: Evaluation Study.JMIR mHealth and uHealth · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The objective was to develop a closed-loop (CL) artificial pancreas (AP) control system that uses continuous measurements of glucose concentration and physiological variables, integrated with a hypoglycemia early alarm module to regulate glucose concentration and prevent hypoglycemia. Eleven open-loop (OL) and 9 CL experiments were performed. A multivariable adaptive artificial pancreas (MAAP) system was used for the first 6 CL experiments. An integrated multivariable adaptive artificial pancreas (IMAAP) system consisting of MAAP augmented with a hypoglycemia early alarm system was used during the last 3 CL experiments. Glucose values and physical activity information were measured and transferred to the controller every 10 minutes and insulin suggestions were entered to the pump manually. All experiments were designed to be close to real-life conditions. Severe hypoglycemic episodes were seen several times during the OL experiments. With the MAAP system, the occurrence of severe hypoglycemia was decreased significantly (P < .01). No hypoglycemia was seen with the IMAAP system. There was also a significant difference (P < .01) between OL and CL experiments with regard to percentage of glucose concentration (54% vs 58%) that remained within target range (70-180 mg/dl). Integration of an adaptive control and hypoglycemia early alarm system was able to keep glucose concentration values in target range in patients with type 1 diabetes. Postprandial hypoglycemia and exercise-induced hypoglycemia did not occur when this system was used. Physical activity information improved estimation of the blood glucose concentration and effectiveness of the control system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.