ArticleBiology of reproduction2014
Age- and species-dependent infiltration of macrophages into the testis of rats and mice exposed to mono-(2-Ethylhexyl) phthalate (MEHP).
Article in Biology of reproduction, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Identification and characterization of a novel CD2-positive cell population in the seminiferous tubule of Fischer CDF344 rats†.Biology of reproduction · 2025Article
- Dose-dependent testis infiltration of peritubular macrophages after MEHP exposure of Peri-pubertal rats and their role in the recovery of spermatogenesis.Toxicology research · 2025Article
- Article
- Phthalates toxicityHeliyon · 2025Article
- The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Responses of peritubular macrophages and the testis transcriptome profiles of peripubertal and adult rodents exposed to an acute dose of MEHP.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- The Impact of Chronic Phthalate Exposure on Rodent Anxiety and Cognition.Biological psychiatry global open science · 2024Review
- Peritubular Macrophages Are Recruited to the Testis of Peripubertal Rats After Mono-(2-Ethylhexyl) Phthalate Exposure and Is Associated With Increases in the Numbers of Spermatogonia.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- The gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl) phthalate.Environmental science and pollution research international · 2020Article
- Histopathologic, apoptotic and autophagic, effects of prenatal bisphenol A and/or di(2-ethylhexyl) phthalate exposure on prepubertal rat testis.Environmental science and pollution research international · 2020Article
- MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis.Reproduction (Cambridge, England) · 2018Article
- Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism.Scientific reports · 2017Article
- An overview of a Sertoli cell transplantation model to study testis morphogenesis and the role of the Sertoli cells in immune privilege.Environmental epigenetics · 2017Review
- Mono-(2-ethylhexyl) phthalate-induced Sertoli cell injury stimulates the production of pro-inflammatory cytokines in Fischer 344 rats.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Protective Effects of Genistein against Mono-(2-ethylhexyl) Phthalate-Induced Oxidative Damage in Prepubertal Sertoli Cells.BioMed research international · 2017Article
- Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis.Seminars in cell & developmental biology · 2016Review
- The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions.Toxicology in vitro : an international journal published in association with BIBRA · 2016Article
- Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice.Molecular and cellular endocrinology · 2014Article
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism by which noninfectious testicular inflammation results in infertility is poorly understood. Here the infiltration of CD11b+ immunoreactive testicular interstitial cells (neutrophil, macrophages, dendritic cells) in immature (Postnatal Day [PND] 21, 28, and 35) and adult (PND 56) Fischer rats is described at 12, 24, and 48 h after an oral dose of 1 g/kg mono-(2-ethylhexyl) phthalate (MEHP), a well-described Sertoli cell toxicant. Increases of CD11b+ cells are evident 12 h after MEHP exposure in PND 21 and 28 rats. In PND 28 rats, CD11b+ cells remained significantly elevated at 48 h, while in PND 21 rats, it returned to control levels by 24 h. The peak number of CD11b+ cells in PND 35 rat testis is delayed until 24 h, but remains significantly elevated at 48 h. In PND 56 rats, no increase in CD11b+ cells occurs after MEHP exposure. In PND 21, 28, and 35 rats, a significant increase in monocyte chemoattractant protein-1 (MCP-1) by peritubular myoid cells occurs 12 h after MEHP. Interestingly, MEHP treatment of C57BL/6J mice did not incite an infiltration of CD11b+ cells at either PND 21 or 28. The peak level of germ cell apoptosis observed 24 h after MEHP exposure in young rats is not seen in mice at any age or in PND 56 rats. Taken together, these findings implicate MCP-1 released by peritubular myoid cells in provoking the migration of CD11b+ cells into the immature rat testis early after MEHP exposure and point to a role for CD11b+ cells in triggering germ cell apoptosis in an age- and species-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.