ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Reductions in central venous pressure by lower body negative pressure or blood loss elicit similar hemodynamic responses.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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Who cites it
47 citing papers in PubMed, 96 citations in OpenAlex.
- Low-dose sufentanil does not affect tolerance to LBNP-induced central hypovolemia or blood pressure responses during a cold pressor test.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Trial
- Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans.Prehospital emergency care · 2023Trial
- Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Lower body negative pressure to safely reduce intracranial pressure.The Journal of physiology · 2019Trial
- Early detection of hypovolemia by venous pulse wave velocity and vena cava ultrasound imaging.European journal of applied physiology · 2026Article
- A noninvasive bioengineering technology for testing medical monitoring capabilities for conditions of human hypovolemia and hypotension.Frontiers in bioengineering and biotechnology · 2026Review
- Human and animal models for studying hemorrhagic shock.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Hemorrhage at high altitude: impact of sustained hypobaric hypoxia on cerebral blood flow, tissue oxygenation, and tolerance to simulated hemorrhage in humans.European journal of applied physiology · 2024Article
- Compensatory reserve index during central hypovolemia and volume loading in healthy young and older hyperthermic adults: A pilot study.Physiological reports · 2024Article
- Nine treatments of 1000 mL therapeutic phlebotomy in a subject with polycythemia: A case report.Physiological reports · 2024Article
- Non-invasive biomarkers for detecting progression toward hypovolemic cardiovascular instability in a lower body negative pressure model.Scientific reports · 2024Article
- The effect of oscillatory hemodynamics on the cardiovascular responses to simulated hemorrhage during isocapnia.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Superiority of compensatory reserve measurement compared with the Shock index for early and accurate detection of reduced central blood volume status.The journal of trauma and acute care surgery · 2023Article
- Impact of Increasing Lower Body Negative Pressure and Its Abrupt Release on Left Ventricular Hemodynamics in Anesthetized Pigs.Journal of clinical medicine · 2022Article
- AI-Enabled Advanced Development for Assessing Low Circulating Blood Volume for Emergency Medical Care: Comparison of Compensatory Reserve Machine-Learning Algorithms.Sensors (Basel, Switzerland) · 2022Article
- A comparison of protocols for simulating hemorrhage in humans: step versus ramp lower body negative pressure.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Central Hypovolemia Detection During Environmental Stress-A Role for Artificial Intelligence?Frontiers in physiology · 2021Review
- Vasopressin and Breathing: Review of Evidence for Respiratory Effects of the Antidiuretic Hormone.Frontiers in physiology · 2021Review
- Preliminary Evidence of Orthostatic Intolerance and Altered Cerebral Vascular Control Following Sport-Related Concussion.Frontiers in neurology · 2021Article
- Lower-limb venous distension reflex and orthostatic tolerance in young healthy humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The purpose of this study was to compare hemodynamic and blood analyte responses to reduced central venous pressure (CVP) and pulse pressure (PP) elicited during graded lower body negative pressure (LBNP) to those observed during graded blood loss (BL) in conscious humans. We hypothesized that the stimulus-response relationships of CVP and PP to hemodynamic responses during LBNP would mimic those observed during BL. We assessed CVP, PP, heart rate, mean arterial pressure (MAP), and other hemodynamic markers in 12 men during LBNP and BL. Blood samples were obtained for analysis of catecholamines, hematocrit, hemoglobin, arginine vasopressin, and blood gases. LBNP consisted of 5-min stages at 0, 15, 30, and 45 mmHg of suction. BL consisted of 5 min at baseline and following three stages of 333 ml of hemorrhage (1,000 ml total). Individual r(2) values and linear regression slopes were calculated to determine whether the stimulus (CVP and PP)-hemodynamic response trajectories were similar between protocols. The CVP-MAP trajectory was the only CVP-response slope that was statistically different during LBNP compared with BL (0.93 ± 0.27 vs. 0.13 ± 0.26; P = 0.037). The PP-heart rate trajectory was the only PP-response slope that was statistically different during LBNP compared with BL (-1.85 ± 0.45 vs. -0.46 ± 0.27; P = 0.024). Norepinephrine, hematocrit, and hemoglobin were all lower at termination in the BL protocol compared with LBNP (P < 0.05). Consistent with our hypothesis, LBNP mimics the hemodynamic stimulus-response trajectories observed during BL across a significant range of CVP in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.