ArticleJournal of cell science2014
ER stress signaling requires RHD3, a functionally conserved ER-shaping GTPase.
Article in Journal of cell science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- COST1 stimulates RHD3 GTPase activity to maintain ER morphology and plant growth inScience advances · 2026Article
- A glossary of plant cell structures: Current insights and future questions.The Plant cell · 2022Review
- ROOT HAIR DEFECTIVE3 Is a Receptor for Selective Autophagy of the Endoplasmic Reticulum inFrontiers in plant science · 2022Article
- Maintaining the structural and functional homeostasis of the plant endoplasmic reticulum.Developmental cell · 2021Review
- Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress.Frontiers in neuroscience · 2021Review
- The plant endoplasmic reticulum: an organized chaos of tubules and sheets with multiple functions.Journal of microscopy · 2020Review
- A Plasmodium homolog of ER tubule-forming proteins is required for parasite virulence.Molecular microbiology · 2020Article
- Naringenin AmelioratesFrontiers in neuroscience · 2019Article
- Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum.Nature communications · 2018Article
- Salicylic acid-independent role of NPR1 is required for protection from proteotoxic stress in the plant endoplasmic reticulum.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The odd one out: Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid regulation.Scientific reports · 2018Article
- Activation of the Transducers of Unfolded Protein Response in Plants.Frontiers in plant science · 2018Review
- Advances in Plant ER Architecture and Dynamics.Plant physiology · 2018Review
- In Brachypodium a complex signaling is actuated to protect cells from proteotoxic stress and facilitate seed filling.Planta · 2017Article
- A GTPase-Dependent Fine ER Is Required for Localized Secretion in Polarized Growth of Root Hairs1.Plant physiology · 2016Article
- Unfolded protein response in plants: one master, many questions.Current opinion in plant biology · 2015Review
- ER - the key to the highway.Current opinion in plant biology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Whether structure and function are correlated features of organelles is a fundamental question in cell biology. Here, we have assessed the ability of Arabidopsis mutants with a defective endoplasmic reticulum (ER) structure to invoke the unfolded protein response (UPR), an essential ER signaling pathway. Through molecular and genetic approaches, we show that loss of the ER-shaping GTPase Root Hair Defective 3 (RHD3) specifically disrupts the UPR by interfering with the mRNA splicing function of the master regulator IRE1. These findings establish a new role for RHD3 in the ER and support specificity of the effects of ER-shaping mutations on ER function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.