ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2014
Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis in oocytes.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- L-palmitoylcarnitine supplementation improves oocyte quality and embryo development derived from obese mice.Fundamental research · 2026Article
- Age-associated accumulation of RAB9 disrupts oocyte meiosis.Aging cell · 2025Article
- VPS34 Governs Oocyte Developmental Competence by Regulating Mito/Autophagy: A Novel Insight into the Significance of RAB7 Activity and Its Subcellular Location.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The role of Golgi complex proteins in cell division and consequences of their dysregulation.Frontiers in cell and developmental biology · 2024Review
- CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.Nature communications · 2022Article
- RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging.Autophagy · 2022Article
- Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.Molecular cell · 2020Article
- HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation.Cell cycle (Georgetown, Tex.) · 2020Article
- ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.Frontiers in cell and developmental biology · 2020Article
- Article
- Rab24 functions in meiotic apparatus assembly and maturational progression in mouse oocyte.Cell cycle (Georgetown, Tex.) · 2019Article
- Loss of CENPF leads to developmental failure in mouse embryos.Cell cycle (Georgetown, Tex.) · 2019Article
- SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation.Aging cell · 2018Article
- Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality.Aging cell · 2018Article
- HDAC6 inhibition disrupts maturational progression and meiotic apparatus assembly in mouse oocytes.Cell cycle (Georgetown, Tex.) · 2018Article
- Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis.Nucleic acids research · 2017Article
- GTPase-activating protein Elmod2 is essential for meiotic progression in mouse oocytes.Cell cycle (Georgetown, Tex.) · 2017Article
- Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs.Oncotarget · 2016Article
- RNA- binding protein Stau2 is important for spindle integrity and meiosis progression in mouse oocytes.Cell cycle (Georgetown, Tex.) · 2016Article
- Rab3A, Rab27A, and Rab35 regulate different events during mouse oocyte meiotic maturation and activation.Histochemistry and cell biology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Rab GTPases are highly conserved components of vesicle trafficking pathways. Rab5, as a master regulator of endocytic trafficking, has been shown to function in membrane tethering and docking. However, the function of Rab5 in meiosis has not been addressed. Here, we report elongated spindles and misaligned chromosomes, with kinetochore-microtubule misattachments, on specific depletion of Rab5a in mouse oocytes. Moreover, the localization and levels of centromere protein F (CENPF), a component of the nuclear matrix, are severely reduced at kinetochores in metaphase oocytes following Rab5a knockdown. Consistent with this finding, nuclear lamina disassembly in the transition from prophase arrest to meiosis I is also impaired in Rab5a-depleted oocytes. Notably, oocyte-specific ablation of CENPF phenocopies the meiotic defects resulting from Rab5a knockdown. In summary, our data support a model where Rab5a-positive vesicles, likely through interaction with nuclear lamina, modulate CENPF localization and levels at centromeres, consequently ensuring proper spindle length and kinetochore-microtubule attachment in meiotic oocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.