ArticleNature cell biology2014
A centrosomal route for cancer genome instability.
Article in Nature cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Prognostic significance of NEK2 in human solid tumors: a systematic review and meta-analysis.Bioscience reports · 2019Pooled it
- Targeting TRIP13 for overcoming anticancer drug resistance (Review).Oncology reports · 2023Article
- Whole-Genome Doubling as a source of cancer: how, when, where, and why?Frontiers in cell and developmental biology · 2023Review
- Article
- Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance.Oncogene · 2021Article
- Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer.Biomedical reports · 2020Article
- Review
- Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium-specific Deletion ofMolecular cancer research : MCR · 2019Article
- Insights into a Crucial Role of TRIP13 in Human Cancer.Computational and structural biotechnology journal · 2019Review
- Article
- Plk1 overexpression induces chromosomal instability and suppresses tumor development.Nature communications · 2018Article
- Fanconi anaemia and cancer: an intricate relationship.Nature reviews. Cancer · 2018Review
- Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability.NPJ systems biology and applications · 2018Article
- The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.Scientific reports · 2017Article
- The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.Oncogene · 2017Article
- Revisiting tumour aneuploidy - the place of ploidy assessment in the molecular era.Nature reviews. Clinical oncology · 2016Review
- p53 in survival, death and metabolic health: a lifeguard with a licence to kill.Nature reviews. Molecular cell biology · 2015Review
- Issues in interpreting the in vivo activity of Aurora-A.Expert opinion on therapeutic targets · 2015Review
- Article
- Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A.Cell cycle (Georgetown, Tex.) · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the widespread occurrence of aneuploidy in cancer cells, the molecular causes for chromosomal instability are not well established. Cyclin B2 is now shown to control a pathway - involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 - the alteration of which causes defective centrosome separation, aneuploidy and tumour development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.