ArticlePloS one2014
Synchronization of developmental processes and defense signaling by growth regulating transcription factors.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 84 citations in OpenAlex.
- SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.Plant, cell & environment · 2026Article
- The genome ofHorticulture research · 2025Article
- Genome-wide characterization of GRF-GIF transcriptional modules in kenaf (Hibiscus cannabinus L.) reveals their roles in plant development and multi-stress adaptation.Functional & integrative genomics · 2025Article
- Genome‑wide identifcation and expression analysis of growth-regulating factors under drought in Brassica juncea.Scientific reports · 2024Article
- Potential Roles of the GRF Transcription Factors in Sorghum Internodes during Post-Reproductive Stages.Plants (Basel, Switzerland) · 2024Article
- Genome-wide identification and expression profiling of growth‑regulating factor (GRF) and GRF‑interacting factor (GIF) gene families in chickpea and pigeonpea.Scientific reports · 2024Article
- Review
- Genome-wide molecular evolution analysis of the GRF and GIF gene families in Plantae (Archaeplastida).BMC genomics · 2024Article
- Genome-Wide Analysis of Flax (International journal of molecular sciences · 2023Article
- Whole-genome identification and expression profiling of growth-regulating factor (GRF) and GRF-interacting factor (GIF) gene families in Panax ginseng.BMC genomics · 2023Article
- Growth-regulating factor 15-mediated gene regulatory network enhances salt tolerance in poplar.Plant physiology · 2023Article
- Characterization of microRNAs and Target Genes inPlants (Basel, Switzerland) · 2023Article
- Transcriptomic and metabolomic profiling reveals the drought tolerance mechanism ofFrontiers in plant science · 2023Article
- Genome-wide identification, phylogeny, and expression analysis of GRF transcription factors in pineapple (Frontiers in plant science · 2023Article
- Genome-wide characterization and expression analysis of the growth-regulating factor family in Saccharum.BMC plant biology · 2022Article
- Construction of two regulatory networks related to salt stress and lignocellulosic synthesis under salt stress based on a Populus davidiana × P. bolleana transcriptome analysis.Plant molecular biology · 2022Article
- Genome-Wide Identification and Characterization of Growth Regulatory Factor Family Genes inInternational journal of molecular sciences · 2022Article
- Functional conservation and divergence in plant-specificOpen life sciences · 2022Article
- Jasmonic Acid-Dependent MYC Transcription Factors Bind to a Tandem G-Box Motif in theInternational journal of molecular sciences · 2021Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth regulating factors (GRFs) are a conserved class of transcription factor in seed plants. GRFs are involved in various aspects of tissue differentiation and organ development. The implication of GRFs in biotic stress response has also been recently reported, suggesting a role of these transcription factors in coordinating the interaction between developmental processes and defense dynamics. However, the molecular mechanisms by which GRFs mediate the overlaps between defense signaling and developmental pathways are elusive. Here, we report large scale identification of putative target candidates of Arabidopsis GRF1 and GRF3 by comparing mRNA profiles of the grf1/grf2/grf3 triple mutant and those of the transgenic plants overexpressing miR396-resistant version of GRF1 or GRF3. We identified 1,098 and 600 genes as putative targets of GRF1 and GRF3, respectively. Functional classification of the potential target candidates revealed that GRF1 and GRF3 contribute to the regulation of various biological processes associated with defense response and disease resistance. GRF1 and GRF3 participate specifically in the regulation of defense-related transcription factors, cell-wall modifications, cytokinin biosynthesis and signaling, and secondary metabolites accumulation. GRF1 and GRF3 seem to fine-tune the crosstalk between miRNA signaling networks by regulating the expression of several miRNA target genes. In addition, our data suggest that GRF1 and GRF3 may function as negative regulators of gene expression through their association with other transcription factors. Collectively, our data provide new insights into how GRF1 and GRF3 might coordinate the interactions between defense signaling and plant growth and developmental pathways.
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