ArticleScientific reports2014
Characterisation of cytoplasmic DNA complementary to non-retroviral RNA viruses in human cells.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Article
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- Antiviral Activity of an Endogenous Parvoviral Element.Viruses · 2023Article
- The Impact of Deleting Stem-Loop 1 of Epstein-Barr Virus-Encoded RNA 1 on Cell Proliferation.Viruses · 2022Article
- Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 Replication.Microbiology and molecular biology reviews : MMBR · 2022Review
- Mouse circulating extracellular vesicles contain virus-derived siRNAs active in antiviral immunity.The EMBO journal · 2022Article
- BmCPV-Derived Circular DNA vcDNA-S7 Mediated byFrontiers in immunology · 2022Article
- Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells.Cell research · 2021Article
- Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells.PLoS pathogens · 2021Article
- Transcriptome Analysis Reveals Higher Levels of Mobile Element-Associated Abnormal Gene Transcripts in Temporal Lobe Epilepsy Patients.Frontiers in genetics · 2021Article
- Flu RNA Vaccine: A Game Changer?Vaccines · 2020Article
- Innate Immune DNA Sensing of Flaviviruses.Viruses · 2020Review
- Molecular Properties and Evolutionary Origins of a Parvovirus-Derived Myosin Fusion Gene in Guinea Pigs.Journal of virology · 2019Article
- Small RNA-based antimicrobial immunity.Nature reviews. Immunology · 2019Review
- L1 retrotransposition in the soma: a field jumping ahead.Mobile DNA · 2018Review
- Intracellular Antiviral Immunity.Advances in virus research · 2018Review
- Potential Links between Hepadnavirus and Bornavirus Sequences in the Host Genome and Cancer.Frontiers in microbiology · 2017Review
- Article
- Immune responses to endogenous retroelements: taking the bad with the good.Nature reviews. Immunology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
The synthesis and subsequent genomic integration of DNA that is complementary to the genomes of non-retroviral RNA viruses are rarely observed. However, upon infection of various human cell lines and primary fibroblasts with the vesicular stomatitis virus (VSV), we detected DNA complementary to the VSV RNA. The VSV DNA was detected in the cytoplasm as single-stranded DNA fully complementary to the viral mRNA from the poly(A) region to the 7-methyl guanosine cap. The formation of this DNA was cell-dependent. Experimentally, we found that the transduction of cells that do not produce VSV DNA with the long interspersed nuclear element 1 and their infection with VSV could lead to the formation of VSV DNA. Viral DNA complementary to other RNA viruses was also detected in the respective infected human cells. Thus, the genetic information of the non-retroviral RNA virus genome can flow into the DNA of mammalian cells expressing LINE-1-like elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.