ArticleNucleic acids research2014
DDI-CPI, a server that predicts drug-drug interactions through implementing the chemical-protein interactome.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
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- In Silico and In Vitro Approach for Evaluation of the Anti-Inflammatory and Antioxidant Potential of Mygalin.International journal of molecular sciences · 2023Article
- Drug-drug interaction prediction: databases, web servers and computational models.Briefings in bioinformatics · 2023Review
- On the road to explainable AI in drug-drug interactions prediction: A systematic review.Computational and structural biotechnology journal · 2022Review
- Evaluation of the Influence of Zhenwu Tang on the Pharmacokinetics of Digoxin in Rats Using HPLC-MS/MS.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Deciphering the Key Pharmacological Pathways and Targets of Yisui Qinghuang Powder That Acts on Myelodysplastic Syndromes Using a Network Pharmacology-Based Strategy.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Finding Causal Mechanistic Drug-Drug Interactions from Observational Data.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020Article
- Evaluation of knowledge graph embedding approaches for drug-drug interaction prediction in realistic settings.BMC bioinformatics · 2019Article
- Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work.European journal of medicinal chemistry · 2019Review
- DrugComb: an integrative cancer drug combination data portal.Nucleic acids research · 2019Article
- Assessment of the cardiovascular adverse effects of drug-drug interactions through a combined analysis of spontaneous reports and predicted drug-target interactions.PLoS computational biology · 2019Article
- Leveraging genetic interactions for adverse drug-drug interaction prediction.PLoS computational biology · 2019Article
- Detecting drug communities and predicting comprehensive drug-drug interactions via balance regularized semi-nonnegative matrix factorization.Journal of cheminformatics · 2019Article
- KGDDS: A System for Drug-Drug Similarity Measure in Therapeutic Substitution based on Knowledge Graph Curation.Journal of medical systems · 2019Article
- TMFUF: a triple matrix factorization-based unified framework for predicting comprehensive drug-drug interactions of new drugs.BMC bioinformatics · 2018Article
- Pattern Discovery from High-Order Drug-Drug Interaction Relations.Journal of healthcare informatics research · 2018Article
- An Integrated Local Classification Model of Predicting Drug-Drug Interactions via Dempster-Shafer Theory of Evidence.Scientific reports · 2018Article
- Predicting and understanding comprehensive drug-drug interactions via semi-nonnegative matrix factorization.BMC systems biology · 2018Article
- PyBioMed: a python library for various molecular representations of chemicals, proteins and DNAs and their interactions.Journal of cheminformatics · 2018Article
- Mechanisms and the clinical relevance of complex drug-drug interactions.Clinical pharmacology : advances and applications · 2018Review
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Authors and funding
8 authors.
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Abstract
Drug-drug interactions (DDIs) may cause serious side-effects that draw great attention from both academia and industry. Since some DDIs are mediated by unexpected drug-human protein interactions, it is reasonable to analyze the chemical-protein interactome (CPI) profiles of the drugs to predict their DDIs. Here we introduce the DDI-CPI server, which can make real-time DDI predictions based only on molecular structure. When the user submits a molecule, the server will dock user's molecule across 611 human proteins, generating a CPI profile that can be used as a feature vector for the pre-constructed prediction model. It can suggest potential DDIs between the user's molecule and our library of 2515 drug molecules. In cross-validation and independent validation, the server achieved an AUC greater than 0.85. Additionally, by investigating the CPI profiles of predicted DDI, users can explore the PK/PD proteins that might be involved in a particular DDI. A 3D visualization of the drug-protein interaction will be provided as well. The DDI-CPI is freely accessible at http://cpi.bio-x.cn/ddi/.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.