ArticleAmerican journal of epidemiology2014
Variation in the association between colorectal cancer susceptibility loci and colorectal polyps by polyp type.
Article in American journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Key genes and pathway differences between serrated polyps and conventional adenomas: insights from multi-omics.Translational cancer research · 2026Article
- Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies.Genome medicine · 2024Article
- Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer.Journal of human genetics · 2022Article
- Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility.Journal of medical genetics · 2020Article
- Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies.International journal of epidemiology · 2020Article
- Association between Hemoglobin Levels and Colorectal Polyps in Asymptomatic Chinese Adults.Gastroenterology research and practice · 2020Article
- Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer.International journal of cancer · 2019Article
- Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma.Cancer cell international · 2019Article
- Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population.Gastroenterology · 2018Article
- Glioblastoma and acute myeloid leukemia: malignancies with striking similarities.Journal of neuro-oncology · 2018Review
- ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer.Oncotarget · 2016Article
- Article
- Molecular phenotypes of colorectal cancer and potential clinical applications.Gastroenterology report · 2015Review
- Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization.Cancer causes & control : CCC · 2015Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
We conducted a case-control study of the association between subsets of colorectal polyps, including adenomas and serrated polyps, and single-nucleotide polymorphisms (SNPs) related to colorectal cancer through prior genome-wide association studies (GWAS). Participants were enrollees in the Group Health Cooperative (Seattle, Washington) aged 24-79 years who received a colonoscopy from 1998 to 2007, donated a buccal or blood sample, and completed a structured questionnaire. We performed genotyping of 13 colorectal cancer susceptibility SNPs. Polytomous logistic regression models were used to estimate odds ratios and 95% confidence intervals for associations between polyps and the colorectal cancer risk allele for each SNP under a log-additive model. Analyses included 781 controls, 489 cases with adenoma, 401 cases with serrated polyps, and 188 cases with both polyp types. The following SNPs were associated with advanced adenomas: rs10936599, rs10795668, rs16892766, and rs9929218 (P < 0.05). For nonadvanced adenomas and for serrated polyps overall, only rs961253 was statistically significant (P < 0.05). These associations were in the same directions as those in prior colorectal cancer GWAS. No SNP was significantly associated with hyperplastic polyps, and only rs6983267 was significantly associated with sessile serrated polyps, but this association was opposite of that found in colorectal cancer GWAS. Our results suggest that the association between colorectal cancer susceptibility SNPs and colorectal polyps varies by polyp type.
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