ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2014
Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Mouse models of eosinophilic esophagitis: molecular and translational insights.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Animal models of eosinophilic esophagitis.Journal of leukocyte biology · 2024Review
- Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases.The Journal of allergy and clinical immunology · 2024Review
- Mast cell-pain connection in eosinophilic esophagitis.Allergy · 2022Article
- Models and Tools for Investigating Eosinophilic Esophagitis at the Bench.Frontiers in immunology · 2022Review
- Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus.Molecules (Basel, Switzerland) · 2021Review
- Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.Scientific reports · 2019Article
- Management of refractory eosinophilic oesophagitis.Nature reviews. Gastroenterology & hepatology · 2017Review
- TRP channel functions in the gastrointestinal tract.Seminars in immunopathology · 2016Review
- Mechanisms of the adenosine A2A receptor-induced sensitization of esophageal C fibers.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Article
- Eosinophilic Esophagitis and Gastroenteritis.Current allergy and asthma reports · 2015Review
- Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Translating new developments in eosinophilic esophagitis pathogenesis into clinical practice.Current treatment options in gastroenterology · 2015Article
- Role of satellite glial cells in gastrointestinal pain.Frontiers in cellular neuroscience · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Eosinophilic esophagitis (EoE) is characterized with eosinophils and mast cells predominated allergic inflammation in the esophagus and present with esophageal dysfunctions such as dysphagia, food impaction, and heartburn. However, the underlying mechanism of esophageal dysfunctions is unclear. This study aims to determine whether neurons in the vagal sensory ganglia are modulated in a guinea pig model of EoE. Animals were actively sensitized by ovalbumin (OVA) and then challenged with aerosol OVA inhalation for 2 wk. This results in a mild esophagitis with increases in mast cells and eosinophils in the esophageal wall. Vagal nodose and jugular neurons were disassociated, and their responses to acid, capsaicin, and transient receptor potential vanilloid type 1 (TRPV1) antagonist AMG-9810 were studied by calcium imaging and whole cell patch-clamp recording. Compared with naïve animals, antigen challenge significantly increased acid responsiveness in both nodose and jugular neurons. Their responses to capsaicin were also increased after antigen challenge. AMG-9810, at a concentration that blocked capsaicin-evoked calcium influx, abolished the increase in acid-induced activation in both nodose and jugular neurons. Vagotomy strongly attenuated those increased responses of nodose and jugular neurons to both acid and capsaicin induced by antigen challenge. These data for the first time demonstrated that prolonged antigen challenge significantly increases acid responsiveness in vagal nodose and jugular ganglia neurons. This sensitization effect is mediated largely through TRPV1 and initiated at sensory nerve endings in the peripheral tissues. Allergen-induced enhancement of responsiveness to noxious stimulation by acid in sensory nerve may contribute to the development of esophageal dysfunctions such as heartburn in EoE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.