ArticlePloS one2014
KLF2--a negative regulator of pre-B cell clonal expansion and B cell activation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
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- Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.Cell discovery · 2023Article
- The 'omics of obesity in B-cell acute lymphoblastic leukemia.Journal of the National Cancer Institute. Monographs · 2023Article
- The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia.Blood advances · 2023Article
- Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing.Frontiers in immunology · 2023Review
- Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution.Frontiers in immunology · 2023Article
- Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses.Mucosal immunology · 2022Article
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- Krüppel-like Factor 2 (KLF2) in Immune Cell Migration.Vaccines · 2021Review
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- Genomic deregulation of PRMT5 supports growth and stress tolerance in chronic lymphocytic leukemia.Scientific reports · 2020Article
- An optimized workflow for single-cell transcriptomics and repertoire profiling of purified lymphocytes from clinical samples.Scientific reports · 2020Article
- The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh.The Journal of experimental medicine · 2017Article
- Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.Nature immunology · 2017Article
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- A novel role for KLF14 in T regulatory cell differentiation.Cellular and molecular gastroenterology and hepatology · 2015Article
- The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.Immunity · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maturation as well as antigen-dependent activation of B cells is accompanied by alternating phases of proliferation and quiescence. We and others have previously shown that Krüppel-like factor 2 (KLF2), a regulator of T cell quiescence and migration, is upregulated in small resting precursor (pre)-B cells after assembly of the immature pre-B cell receptor (pre-BCR) and is downregulated upon antigen-induced proliferation of mature B cells. These findings suggest that KLF2, besides its function in maintaining follicular B cell identity, peripheral B cell homeostasis and homing of antigen-specific plasma cells to the bone marrow, also controls clonal expansion phases in the B cell lineage. Here, we demonstrate that enforced expression of KLF2 in primary pre-B cells results in a severe block of pre-BCR-induced proliferation, upregulation of the cell cycle inhibitors p21 and p27 and downregulation of c-myc. Furthermore, retroviral KLF2 transduction of primary B cells impairs LPS-induced activation, favors apoptosis and results in reduced abundance of factors, such as AID, IRF4 and BLIMP1, that control the antigen-dependent phase of B cell activation and plasma cell differentiation. Hence, we conclude that KLF2 is not only a key player in terminating pre-B cell clonal expansion but also a potent suppressor of B cell activation.
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