ArticleScientific reports2014
Current breast cancer proliferative markers correlate variably based on decoupled duration of cell cycle phases.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
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- Predicting Neoadjuvant Treatment Response in Triple-Negative Breast Cancer Using Machine Learning.Diagnostics (Basel, Switzerland) · 2023Article
- An Immunohistochemical Study of Proliferation of Human Fetal Heart Cardiomyocyte With Phospho-Histone H3 Antibody.Cureus · 2023Article
- Ex vivo expansion of circulating tumour cells (CTCs).Scientific reports · 2023Article
- Improving mitotic cell counting accuracy and efficiency using phosphohistone-H3 (PHH3) antibody counterstained with haematoxylin and eosin as part of breast cancer grading.Histopathology · 2023Article
- Loss of POGZ alters neural differentiation of human embryonic stem cells.Molecular and cellular neurosciences · 2022Article
- MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma.Virchows Archiv : an international journal of pathology · 2022Article
- Coxsackievirus B3 Infection Early in Pregnancy Induces Congenital Heart Defects Through Suppression of Fetal Cardiomyocyte Proliferation.Journal of the American Heart Association · 2021Article
- Article
- The Proper Ki-67 Cut-Off in Hormone Responsive Breast Cancer: A Monoinstitutional Analysis with Long-Term Follow-Up.Breast cancer (Dove Medical Press) · 2021Article
- TDP-43 dysfunction results in R-loop accumulation and DNA replication defects.Journal of cell science · 2020Article
- Utility of PHH3 in Evaluation of Mitotic Index in Breast Carcinoma and Impact on Tumor Grade.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids.Neoplasia (New York, N.Y.) · 2019Article
- The value of phosphohistone H3 as a proliferation marker for evaluating invasive breast cancers: A comparative study with Ki67.Oncotarget · 2017Article
- Association Between Phosphorylated Histone H3 and Oncotype DX Recurrence Scores in Breast Cancer.Applied immunohistochemistry & molecular morphology : AIMM · 2017Article
- Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells.NPJ breast cancer · 2017Article
- Image Analysis in Surgical Pathology.Surgical pathology clinics · 2016Review
- Effect of tamoxifen and raloxifene on the proliferative activity of the breast epithelium in premenopausal women.Clinical Medicine Insights. Oncology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitotic count, PhH3, and MIB-1 are used as measures of the proportion of proliferating malignant cells in surgical pathology. They highlight different stages of the cell cycle, but little is known about how this affects their counts. This study assesses the strength of their correlations and attempts to determine the relationship between them. Proliferation counts for forty-nine consecutive cases of invasive breast carcinomas were analyzed, with the same tumor area on each stain counted using digital image analysis. The integrated optical density (IOD) of nuclei was measured as an approximation of nuclear DNA content. PhH3 strongly correlated with mitotic count (r = 0.94). Weaker correlations were found between MIB-1 versus PhH3 (r = 0.79) and mitotic count (r = 0.83). Nuclear IOD showed stronger correlation with MIB-1 (r = 0.37) than to mitotic count (r = 0.23) and PhH3 (r = 0.34). With evidence from a literature review, it is suggested that the weaker correlations with MIB-1 are not explained by count imprecision or error, but relies on temporal decorrelation between cell cycle phases. Consequences on correlation between these proliferative markers are illustrated by mathematical models.
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