ArticleThe American journal of psychiatry2014
Longitudinal trajectories and associated baseline predictors in youths with bipolar spectrum disorders.
Article in The American journal of psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Parental bipolar disorder, family environment, and offspring psychiatric disorders: A systematic review.Journal of affective disorders · 2020Pooled it
- Childhood factors associated with increased risk for mood episode recurrences in bipolar disorder-A systematic review.Bipolar disorders · 2019Pooled it
- Effects of a Smartphone-Based Self-management Intervention for Individuals With Bipolar Disorder on Relapse, Symptom Burden, and Quality of Life: A Randomized Clinical Trial.JAMA psychiatry · 2023Trial
- Early Family Intervention for Youth at Risk for Bipolar Disorder: Psychosocial and Neural Mediators of Outcome.Current neuropharmacology · 2023Trial
- Tolerability, Safety, and Effectiveness of Two Years of Treatment with Lurasidone in Children and Adolescents with Bipolar Depression.Journal of child and adolescent psychopharmacology · 2021Trial
- Longitudinal trajectories of mood symptoms and global functioning in youth at high risk for bipolar disorder.Journal of affective disorders · 2020Trial
- Classifying Mood Symptom Trajectories in Adolescents With Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Trial
- Early intervention for youth at high risk for bipolar disorder: A multisite randomized trial of family-focused treatment.Early intervention in psychiatry · 2019Trial
- Applications of time-series analysis to mood fluctuations in bipolar disorder to promote treatment innovation: a case series.Translational psychiatry · 2016Trial
- Risk Factors Associated with Longitudinal Trajectories of Mania Symptoms in Youth.medRxiv : the preprint server for health sciences · 2026Article
- Validation and Extension of a Risk Calculator to Predict Mood Recurrence in Young People with Bipolar Disorder.medRxiv : the preprint server for health sciences · 2026Article
- Risk of Pediatric Bipolar Disorder After General Anesthesia in Infants and Toddlers: A Propensity Score-Matched Population-Based Cohort Study.Schizophrenia bulletin · 2024Article
- The effects of mood disorders and childhood trauma on fear of positive and negative evaluation.Acta psychologica · 2022Article
- White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder.Journal of clinical medicine · 2022Article
- Higher socioeconomic status and less parental psychopathology improve prognosis in youths with bipolar disorder.Journal of affective disorders · 2022Article
- Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis.Journal of affective disorders · 2022Article
- Relationship between cognitive flexibility and subsequent course of mood symptoms and suicidal ideation in young adults with childhood-onset bipolar disorder.European child & adolescent psychiatry · 2022Article
- Symptoms and Characteristics of Youth Hospitalized for Depression: Subthreshold Manic Symptoms Can Help Differentiate Bipolar from Unipolar Depression.Journal of child and adolescent psychopharmacology · 2021Article
- Facial emotion recognition and mood symptom course in young adults with childhood-onset bipolar disorder.European archives of psychiatry and clinical neuroscience · 2021Article
- Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders-Longitudinal Study in Adolescent and Young Adult Patients.Journal of clinical medicine · 2021Article
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16 authors.
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Abstract
objectiveThe authors sought to identify and evaluate longitudinal mood trajectories and associated baseline predictors in youths with bipolar disorder.
methodA total of 367 outpatient youths (mean age, 12.6 years) with bipolar disorder with at least 4 years of follow-up were included. After intake, participants were interviewed on average 10 times (SD=3.2) over a mean of 93 months (SD=8.3). Youths and parents were interviewed for psychopathology, functioning, treatment, and familial psychopathology and functioning.
resultsLatent class growth analysis showed four different longitudinal mood trajectories: "predominantly euthymic" (24.0%), "moderately euthymic" (34.6%), "ill with improving course" (19.1%), and "predominantly ill" (22.3%). Within each class, youths were euthymic on average 84.4%, 47.3%, 42.8%, and 11.5% of the follow-up time, respectively. Multivariate analyses showed that better course was associated with higher age at onset of mood symptoms, less lifetime family history of bipolar disorder and substance abuse, and less history at baseline of severe depression, manic symptoms, suicidality, subsyndromal mood episodes, and sexual abuse. Most of these factors were more noticeable in the "predominantly euthymic" class. The effects of age at onset were attenuated in youths with lower socioeconomic status, and the effects of depression severity were absent in those with the highest socioeconomic status.
conclusionsA substantial proportion of youths with bipolar disorder, especially those with adolescent onset and the above-noted factors, appear to be euthymic over extended periods. Nonetheless, continued syndromal and subsyndromal mood symptoms in all four classes underscore the need to optimize treatment.
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