ArticleMolecular and cellular biochemistry2014
Differential expression of miRNAs with metabolic implications in hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus.
Article in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Hibernation-Induced microRNA Expression Promotes Signaling Pathways and Cell Cycle Dysregulation inMetabolites · 2023Article
- Role of MicroRNAs in Extreme Animal Survival Strategies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Muscles in Winter: The Epigenetics of Metabolic Arrest.Epigenomes · 2021Review
- MicroRNA Cues from Nature: A Roadmap to Decipher and Combat Challenges in Human Health and Disease?Cells · 2021Review
- Epigenetic regulation by DNA methyltransferases during torpor in the thirteen-lined ground squirrel Ictidomys tridecemlineatus.Molecular and cellular biochemistry · 2021Article
- Changes in liver microRNA expression and their possible regulatory role in energy metabolism-related genes in hibernating black bears.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- MiR-200-3p Is Potentially Involved in Cell Cycle Arrest by Regulating Cyclin A during Aestivation inCells · 2019Article
- Identification of Differentially Expressed miRNAs in Colorado Potato Beetles (Leptinotarsa decemlineata (Say)) Exposed to Imidacloprid.International journal of molecular sciences · 2017Article
- Differential expression and emerging functions of non-coding RNAs in cold adaptation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Lost in translation: miRNAs and mRNAs in ischemic preconditioning and ischemia/reperfusion injury.Journal of molecular and cellular cardiology · 2016Review
- Up-regulation of Long Non-coding RNA TUG1 in Hibernating Thirteen-lined Ground Squirrels.Genomics, proteomics & bioinformatics · 2016Article
- Identification and profiling of miRNAs in the freeze-avoiding gall moth Epiblema scudderiana via next-generation sequencing.Molecular and cellular biochemistry · 2015Article
- Down but Not Out: The Role of MicroRNAs in Hibernating Bats.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian hibernators undergo significant physiological and biochemical changes when confronted with cold temperatures. Metabolic depression and translational repression are two examples of the various processes impacted during a torpor bout. MicroRNAs (miRNAs), non-coding transcripts that bind to mRNAs, are known regulators of mRNA translation and a growing number of these molecules have been found to be differentially expressed during hibernation. We hypothesized that a group of six miRNAs, with targets involved in various metabolic cascades, is modulated in selected tissues of the hibernating thirteen-lined ground squirrel Ictidomys tridecemlineatus. Expression levels of these miRNAs were assessed in the liver, heart, and skeletal muscle ground squirrel tissues using qRT-PCR. miR-29a, miR-152, miR-195, miR-223, and miR-486 were shown to be up-regulated in the hibernating liver, while miR-378 was shown to be down-regulated in hibernating skeletal muscle tissue samples. Interestingly, fatty acid synthase (FAS), an enzyme involved in fatty acid biosynthesis and a miR-195 target, was shown to be down-regulated in hibernating squirrel liver. This data add to the growing signature of differentially expressed miRNAs during hibernation and puts the light on the potential regulation of fatty acid homeostasis by a miRNA in torpid animals.
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