ArticleThe American journal of psychiatry2014
Prenatal expression patterns of genes associated with neuropsychiatric disorders.
Article in The American journal of psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Prenatal Primary Prevention of Mental Illness by Micronutrient Supplements in Pregnancy.The American journal of psychiatry · 2018Pooled it
- Spatiotemporal brain transcriptomics reveal risk gene hot-spots in major neuropsychiatric disorders.Communications biology · 2026Article
- Maternal health and autism risk: parsing direct and indirect genetic effects using 3-generation family linkage.medRxiv : the preprint server for health sciences · 2026Article
- SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia.Nature communications · 2025Article
- Unraveling the mysteries of schizophrenia: Insights into prefrontal cortex dysfunction and therapeutic implications.World journal of psychiatry · 2025Review
- Spatiotemporal Brain Transcriptomics Reveal Risk Gene Hot-Spots in Major Neuropsychiatric Disorders.Research square · 2025Article
- A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort.Genes · 2025Article
- Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donors' Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia.The American journal of psychiatry · 2024Article
- Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain.Science (New York, N.Y.) · 2024Article
- Developmental Windows for Effects of Choline and Folate on Excitatory and Inhibitory Neurotransmission During Human Gestation.Developmental psychobiology · 2024Article
- Insulin-Like Growth Factor-1 Promotes Synaptogenesis Signaling, a Major Dysregulated Pathway in Malformation of Cortical Development, in a Rat Model.Molecular neurobiology · 2023Article
- Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project.Translational psychiatry · 2023Article
- Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain.medRxiv : the preprint server for health sciences · 2023Article
- Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age.Psychological medicine · 2022Article
- SnapHiC2: A computationally efficient loop caller for single cell Hi-C data.Computational and structural biotechnology journal · 2022Article
- Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV.Journal of psychiatric research · 2021Article
- Prenatal prevention of psychiatric illness and childhood development population-wide.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.Nature neuroscience · 2021Article
- Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex.Epigenetics · 2021Article
- Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.Molecular psychiatry · 2020Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by2014 in review.2014
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveNeurodevelopmental disorders presumably involve events that occur during brain development. The authors hypothesized that neuropsychiatric disorders considered to be developmental in etiology are associated with susceptibility genes that are relatively upregulated during fetal life (i.e., differentially expressed).
methodThe authors investigated the presence of prenatal expression enrichment of susceptibility genes systematically, as composite gene sets associated with six neuropsychiatric disorders in the microarray-based "BrainCloud" dorsolateral prefrontal cortex transcriptome.
resultsUsing a fetal/postnatal log2-fold change threshold of 0.5, genes associated with syndromic neurodevelopmental disorders (N=31 genes, p=3.37×10-3), intellectual disability (N=88 genes, p=5.53×10-3), and autism spectrum disorder (N=242 genes, p=3.45×10-4) were relatively enriched in prenatal transcript abundance, compared with the overall transcriptome. Genes associated with schizophrenia by genome-wide association studies were not preferentially fetally expressed (N=106 genes, p=0.46), nor were genes associated with schizophrenia by exome sequencing (N=212 genes, p=0.21), but specific genes within copy-number variant regions associated with schizophrenia were relatively enriched in prenatal transcript abundance, and genes associated with schizophrenia by meta-analysis were functionally enriched for some neurodevelopmental processes. In contrast, genes associated with neurodegenerative disorders were significantly underexpressed during fetal life (N=46 genes, p=1.67×10-3).
conclusionsThe authors found evidence for relative prenatal enrichment of putative susceptibility genes for syndromic neurodevelopmental disorders, intellectual disability, and autism spectrum disorder. Future transcriptome-level association studies should evaluate regions other than the dorsolateral prefrontal cortex, at other time points, and incorporate further RNA sequencing analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.