Evidence map›Paper›PMID 24873861›Full record

ReviewStem cells translational medicine2014

Concise review: new frontiers in microRNA-based tissue regeneration.

Jessica E Frith, Enzo R Porrello, Justin J Cooper-White

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Microbial genomics · 2022
    Article
  3. Modern Approaches to Acellular Therapy in Bone and Dental Regeneration.International journal of molecular sciences · 2021
    Review
  4. Review
  5. Review
  6. Article
  7. Biomaterials: Foreign Bodies or Tuners for the Immune Response?International journal of molecular sciences · 2019
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. miRNA control of tissue repair and regeneration.The American journal of pathology · 2015
    Review
  13. MicroRNAs regulate bone development and regeneration.International journal of molecular sciences · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jessica E FrithTissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, School of Biomedical Sciences, and School of Chemical Engineering, University of Queensland, St. Lucia, Queensland, Australia; Materials Science and Engineering Division, Commonwealth Scientific and Industrial Research Organisation, Clayton, Victoria, Australia j.frith@uq.edu.au.
Enzo R PorrelloTissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, School of Biomedical Sciences, and School of Chemical Engineering, University of Queensland, St. Lucia, Queensland, Australia; Materials Science and Engineering Division, Commonwealth Scientific and Industrial Research Organisation, Clayton, Victoria, Australia.
Justin J Cooper-WhiteTissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, School of Biomedical Sciences, and School of Chemical Engineering, University of Queensland, St. Lucia, Queensland, Australia; Materials Science and Engineering Division, Commonwealth Scientific and Industrial Research Organisation, Clayton, Victoria, Australia.
University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the role of miRNAs in post-transcriptional gene regulation has come to the fore with strong evidence to indicate an important role for microRNAs (miRNAs) in the regulation of a wide range of fundamental biological processes. Notably, this includes the regulation of both endogenous tissue repair mechanisms and the growth and differentiation of stem cells (both adult and pluripotent). As a result, manipulation of miRNA signaling holds great promise for regenerative medicine, which aims to harness either endogenous or implanted cells to promote tissue repair. However, to fully realize this potential, it will be necessary to combine advances in our biological understanding with new technologies that allow precise spatiotemporal modulation of specific miRNA candidates. In this review, we highlight the role of miRNAs in tissue regeneration, discuss key challenges in translating this knowledge to the clinic, and outline recent technological advances that aim to address these issues. By combining a comprehensive knowledge of miRNA biology with cutting-edge delivery technologies, it is clear that miRNAs hold significant promise for tissue regenerative therapies in the future.

Indexed as

Regenerative MedicineTranslational Research, BiomedicalAnimalsGene Expression Regulation, DevelopmentalGenetic TherapyHumansMicroRNAsRegenerationMicroRNAsDelivery systemsMicroRNAsStem cellsTissue regeneration

Identifiers

PMID24873861
PMCPMC4116250
OpenAlexW2035019995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.