Evidence map›Paper›PMID 24873662›Full record

ArticleNano letters2014

Induction of stemlike cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis.

Sudjit Luanpitpong, Liying Wang, Amruta Manke, Karen H Martin, Amanda Gatesman Ammer, Vincent Castranova, Yong Yang, Yon Rojansakul

Open access · bronzeAbstract read
In one paragraph

Article in Nano letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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  10. A Review on the Respiratory System Toxicity of Carbon Nanoparticles.International journal of environmental research and public health · 2016
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sudjit LuanpitpongPharmaceutical and Pharmacological Sciences Program, ‡Mary Babb Randolph Cancer Center, §Animal Models and Imaging Facility, and ∥Department of Chemical Engineering, West Virginia University , Morgantown, West Virginia 26506, United States.
Liying Wang
Amruta Manke
Karen H Martin
Amanda Gatesman Ammer
Vincent Castranova
Yong Yang
Yon Rojansakul
National Institute for Occupational Safety and Health · US

Funding

WVU &MU NEW FACULTY GRANTSP20RR016477 · NCRR · MARSHALL UNIVERSITY · PI RANKIN, GARY O · 2001 to 2011
$35.5M
THE ROLE OF HEF1 PROTEIN IN INVASION OF METASTATIC BREAST CANCERP20RR016440 · NCRR · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2001 to 2010
$22.8M
West Virginia Flow Cytometry Core FacilityP30GM103488 · NIGMS · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2012 to 2016
$4.8M
Induction of Neoplastic Transformation and Cancer Stem Cells by Carbon NanotubesR01ES022968 · NIEHS · WEST VIRGINIA UNIVERSITY · PI ROJANASAKUL, YON · 2014 to 2019
$1.7M
Prediction and Mechanism of Carbon Nanotube-Induced FibrosisR01HL095579 · NHLBI · WEST VIRGINIA UNIVERSITY · PI ROJANASAKUL, YON · 2010 to 2013
$1.5M
COBRE FOR SIGNAL TRANSDUCTION AND CANCER PHASE IIIP30RR032138 · NCRR · WEST VIRGINIA UNIVERSITY · PI GIBSON, LAURA F. · 2011 to 2011
$1.1M
NCRR NIH HHS P20 RR016440NCRR NIH HHS P20 RR016477NCRR NIH HHS P30 RR032138NHLBI NIH HHS R01 HL095579NHLBI NIH HHS R01-HL095579NIEHS NIH HHS R01 ES022968NIEHS NIH HHS R01-ES022968NIGMS NIH HHS P30 GM103488NIGMS NIH HHS P30 RR032138/GM103488
6 · The paper itself

Abstract

We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model and mechanistic insight on CNT fibrogenesis.

Indexed as

Models, BiologicalCells, CulturedFibroblastsHumansLungNanotubes, CarbonNanotubes, Carbon

Identifiers

PMID24873662
PMCPMC4055043
OpenAlexW2315446568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.