Evidence map›Paper›PMID 24873526›Full record

ArticleAnalytical chemistry2014

Mass spectrometric detection of nanoparticle host-guest interactions in cells.

Bo Yan, Gulen Yesilbag Tonga, Singyuk Hou, Patrick W Fedick, Yi-Cheun Yeh, Felix S Alfonso, Tsukasa Mizuhara, Richard W Vachet, Vincent M Rotello

Abstract read
In one paragraph

Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Paracelsus in nanotoxicology.Particle and fibre toxicology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bo YanDepartment of Chemistry, University of Massachusetts Amherst , Amherst, Massachusetts 01003, United States.
Gulen Yesilbag Tonga
Singyuk Hou
Patrick W Fedick
Yi-Cheun Yeh
Felix S Alfonso
Tsukasa Mizuhara
Richard W Vachet
Vincent M Rotello

Funding

Intracellular Host-Guest Activation of Nanoparticle TherapeuticsR01EB014277 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2012 to 2014
$1.0M
NIBIB NIH HHS R01 EB014277
6 · The paper itself

Abstract

Synthetic host-guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host-guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describe and apply a mass spectrometric method to monitor the association and dissociation of nanoparticle (NP)-based host-guest interactions that integrates NP-assisted laser desorption/ionization (LDI) and matrix assisted laser desoption/ionization (MALDI) mass spectrometry. This LDI/MALDI approach reveals how NP surface functionality affects host-guest interactions in cells, information difficult to achieve using other techniques.

Indexed as

Cucurbit(n)urilsCytoplasmGoldHeLa CellsHumansMacrocyclic CompoundsNanoparticlesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSurface PropertiesCucurbit(n)urilsGoldMacrocyclic Compounds

Identifiers

PMID24873526
PMCPMC4082387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.