ReviewSurgical neurology international2014
Neurosurgical confocal endomicroscopy: A review of contrast agents, confocal systems, and future imaging modalities.
Review in Surgical neurology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02740933 (Demeclocycline Fluorescence for Intraoperative Delineation Brain Tumors), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Demeclocycline Fluorescence for Intraoperative Delineation Brain Tumors
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results.Acta neurochirurgica · 2017Pooled it
- A dual-wavelength blue laser platform for integrated diagnosis and therapy in glioblastoma: preclinical evidence.Lasers in medical science · 2026Article
- Review
- Envisioning the Future of the Neurosurgical Operating Room with the Concept of the Medical Metaverse.Journal of Korean Neurosurgical Society · 2025Article
- Confocal laser endomicroscopy in glial tumors-a histomorphological analysis.Neurosurgical review · 2024Article
- 5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review.Frontiers in neuroscience · 2024Review
- 5-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades.Frontiers in oncology · 2023Article
- [Confocal probe localization algorithm based on region growing and endoscope size prior].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Clinical feasibility of miniaturized Lissajous scanning confocal laser endomicroscopy for indocyanine green-enhanced brain tumor diagnosis.Frontiers in oncology · 2022Article
- Characterization ofFrontiers in oncology · 2022Article
- Soliton microcomb based spectral domain optical coherence tomography.Nature communications · 2021Article
- Redosing of Fluorescein Sodium Improves Image Interpretation During IntraoperativeFrontiers in oncology · 2021Article
- Fluorescence-Guided High-Grade Glioma Surgery More Than Four Hours After 5-Aminolevulinic Acid Administration.Frontiers in neurology · 2021Article
- Capability of physically reasonable OCT-based differentiation between intact brain tissues, human brain gliomas of different WHO grades, and glioma model 101.8 from rats.Biomedical optics express · 2020Article
- Confocal Laser Endomicroscopy Assessment of Pituitary Tumor Microstructure: A Feasibility Study.Journal of clinical medicine · 2020Article
- Image computing for fibre-bundle endomicroscopy: A review.Medical image analysis · 2020Review
- Article
- En-face optical coherence tomography/fluorescence endomicroscopy for minimally invasive imaging using a robotic scanner.Journal of biomedical optics · 2019Article
- Confocal-Assisted Multispectral Fluorescent Microscopy for Brain Tumor Surgery.Frontiers in oncology · 2019Article
- Prospects for Theranostics in Neurosurgical Imaging: Empowering Confocal Laser Endomicroscopy DiagnosticsFrontiers in oncology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical application of fluorescent contrast agents (fluorescein, indocyanine green, and aminolevulinic acid) with intraoperative microscopy has led to advances in intraoperative brain tumor imaging. Their properties, mechanism of action, history of use, and safety are analyzed in this report along with a review of current laser scanning confocal endomicroscopy systems. Additional imaging modalities with potential neurosurgical utility are also analyzed.
methodsA COMPREHENSIVE LITERATURE SEARCH WAS PERFORMED UTILIZING PUBMED AND KEY WORDS: In vivo confocal microscopy, confocal endomicroscopy, fluorescence imaging, in vivo diagnostics/neoplasm, in vivo molecular imaging, and optical imaging. Articles were reviewed that discussed clinically available fluorophores in neurosurgery, confocal endomicroscopy instrumentation, confocal microscopy systems, and intraoperative cancer diagnostics.
resultsCurrent clinically available fluorescent contrast agents have specific properties that provide microscopic delineation of tumors when imaged with laser scanning confocal endomicroscopes. Other imaging modalities such as coherent anti-Stokes Raman scattering (CARS) microscopy, confocal reflectance microscopy, fluorescent lifetime imaging (FLIM), two-photon microscopy, and second harmonic generation may also have potential in neurosurgical applications.
conclusionIn addition to guiding tumor resection, intraoperative fluorescence and microscopy have the potential to facilitate tumor identification and complement frozen section analysis during surgery by providing real-time histological assessment. Further research, including clinical trials, is necessary to test the efficacy of fluorescent contrast agents and optical imaging instrumentation in order to establish their role in neurosurgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.