Evidence map›Paper›PMID 24872815›Full record

ArticleJournal of oncology2014

A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in australia.

Surabhi S Liyanage, Eva Segelov, Aisha Malik, Suzanne M Garland, Sepehr N Tabrizi, Eleanor Cummins, Holly Seale, Bayzidur Rahman, Aye Moa, Andrew P Barbour and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Surabhi S LiyanageSchool of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia.
Eva SegelovDepartment of Medicine, St. Vincent's Hospital Clinical School, The University of New South Wales, Kensington, NSW 2052, Australia.ORCID 0000-0002-4410-6144
Aisha MalikUNSW Medicine, The University of New South Wales, Kensington, NSW 2052, Australia.
Suzanne M GarlandDepartment of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynecology, Murdoch Children's Research Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Sepehr N TabriziDepartment of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynecology, Murdoch Children's Research Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Eleanor CumminsDepartment of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynecology, Murdoch Children's Research Institute, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-6293-9043
Holly SealeSchool of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia.ORCID 0000-0002-1877-5395
Bayzidur RahmanSchool of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia.
Aye MoaSchool of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia.ORCID 0000-0003-4274-6241
Andrew P BarbourDepartment of Surgery, Princess Alexandra Hospital, The University of Queensland, St Lucia, QLD 4072, Australia.
Philip J CroweDepartment of Surgery, Prince of Wales Hospital Clinical School, The University of New South Wales, Kensington, NSW 2052, Australia.
C Raina MacIntyreSchool of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30-5500). All control specimens were negative for HPV. Significantly higher rates of smoking, other aerodigestive cancers, and mortality were seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47-190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed.

Identifiers

PMID24872815
PMCPMC4020305

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.