ArticleClinical epidemiology2014
Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999-2012.
Article in Clinical epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 113 citations in OpenAlex.
- Efficacy of celecoxib versus ibuprofen for the treatment of patients with osteoarthritis of the knee: A randomized double-blind, non-inferiority trial.The Journal of international medical research · 2017Trial
- Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.European journal of clinical pharmacology · 2026Article
- Use of prescribed analgesics before and after a standardised chiropractic care programme among patients with lumbar spinal stenosis: a nationwide cohort study.Chiropractic & manual therapies · 2026Article
- Intoxication in Children From Opioids Prescribed to Family Members.JAMA network open · 2026Article
- Prior Dual Antiplatelet Therapy and Mortality After Intracerebral Hemorrhage: A Danish Nationwide Cohort Study.Journal of the American Heart Association · 2025Article
- Antibiotic Use in the 12 Months Prior to Ileal Pouch-Anal Anastomosis Increases the Risk for Pouchitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Association of Antithrombotic Drug Use With Incident Intracerebral Hemorrhage Location.Neurology · 2024Article
- Cardiovascular safety of using non-steroidal anti-inflammatory drugs for gout: a Danish nationwide case-crossover study.Rheumatology international · 2024Article
- Association of Prior Antithrombotic Drug Use with 90-Day Mortality After Intracerebral Hemorrhage.Clinical epidemiology · 2024Article
- Ibuprofen for Acute Pericarditis and Associated Cardiovascular Risks: A Danish Nationwide, Population-Based Cohort Study.Clinical epidemiology · 2024Article
- Influence of Low-Density Lipoprotein Cholesterol Levels on NSAID-Associated Cardiovascular Risks After Myocardial Infarction: A Population-Based Cohort Study.Clinical epidemiology · 2024Article
- Article
- Twenty-Three-Year Trends in the Use of Potentially Nephrotoxic Drugs in Denmark.Clinical epidemiology · 2023Article
- Venous Thromboembolism and Risk of Cancer in Users of Low-Dose Aspirin: A Danish Population-Based Cohort Study.TH open : companion journal to thrombosis and haemostasis · 2022Article
- Use of Primary Care Data in Research and Pharmacovigilance: Eight Scenarios Where Prescription Data are Absent.Drug safety · 2021Review
- The Validity of Danish Prescription Data to Measure Use of Aspirin and Other Non-Steroidal Anti-Inflammatory Drugs and Quantification of Bias Due to Non-Prescription Drug Use.Clinical epidemiology · 2021Article
- Use of Routinely Collected Registry Data for Undergraduate and Postgraduate Medical Education in Denmark.Journal of European CME · 2021Article
- Cohort profile: CROSS-TRACKS: a population-based open cohort across healthcare sectors in Denmark.BMJ open · 2020Article
- Adverse outcomes and mortality in users of non-steroidal anti-inflammatory drugs who tested positive for SARS-CoV-2: A Danish nationwide cohort study.PLoS medicine · 2020Article
- Cardiovascular effects and safety of (non-aspirin) NSAIDs.Nature reviews. Cardiology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to over-the-counter availability, no consensus exists on whether adequate information on nonsteroidal anti-inflammatory drug (NSAID) use can be obtained from prescription registries.
objectivesTo examine utilization of aspirin and nonaspirin NSAIDs in Denmark between 1999 and 2012 and to quantify the proportion of total sales that was sold on prescription.
methodBased on nationwide data from the Danish Serum Institute and the Danish National Prescription Registry, we retrieved sales statistics for the Danish primary health care sector to calculate 1-year prevalences of prescription users of aspirin or nonaspirin NSAIDs, and to estimate the corresponding proportions of total sales dispensed on prescription.
resultsBoth low-dose aspirin and nonaspirin NSAIDs were commonly used in the Danish population between 1999 and 2012, particularly among elderly individuals. The 1-year prevalence of prescribed low-dose aspirin increased throughout the study period, notably among men. Nonaspirin NSAID use was frequent in all age groups above 15 years and showed a female preponderance. Overall, the prevalence of prescribed nonaspirin NSAIDs decreased moderately after 2004, but substantial variation according to NSAID subtype was observed; ibuprofen use increased, use of all newer selective cyclooxygenase-2 inhibitors nearly ceased after 2004, diclofenac use decreased by nearly 50% after 2008, and naproxen use remained stable. As of 2012, the prescribed proportion of individual-level NSAID sales was 92% for low-dose aspirin, 66% for ibuprofen, and 100% for all other NSAIDs.
conclusionThe potential for identifying NSAID use from prescription registries in Denmark is high. Low-dose aspirin and nonaspirin NSAID use varied substantially between 1999 and 2012. Notably, use of cyclooxygenase-2 inhibitors nearly ceased, use of diclofenac decreased markedly, and naproxen use remained unaltered.
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