ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Modeling inheritance of phase precession in the hippocampal formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 40 citations in OpenAlex.
- Hippocampal Place Cells with NMDARs Do Not Require Excitation and Inhibition to Be Reciprocally Tuned.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal phase precession may be generated by chimera dynamics.Frontiers in neural circuits · 2025Article
- Synaptic learning rules for sequence learning.eLife · 2021Article
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- Article
- Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies.Current biology : CB · 2018Article
- Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells.Nature neuroscience · 2017Article
- Predictive Place-Cell Sequences for Goal-Finding Emerge from Goal Memory and the Cognitive Map: A Computational Model.Frontiers in computational neuroscience · 2017Article
- Article
- Cell Type-Specific Differences in Spike Timing and Spike Shape in the Rat Parasubiculum and Superficial Medial Entorhinal Cortex.Cell reports · 2016Article
- Silencing CA3 disrupts temporal coding in the CA1 ensemble.Nature neuroscience · 2016Article
- Oscillations, Timing, Plasticity, and Learning in the Cerebellum.Cerebellum (London, England) · 2016Review
- Cell-Type Specific Phase Precession in Layer II of the Medial Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Grid Cells and Place Cells: An Integrated View of their Navigational and Memory Function.Trends in neurosciences · 2015Review
- The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity.Nature neuroscience · 2015Article
- Place field expansion after focal MEC inactivations is consistent with loss of Fourier components and path integrator gain reduction.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping.eLife · 2015Article
- Theta sequences are essential for internally generated hippocampal firing fields.Nature neuroscience · 2015Article
- State-dependencies of learning across brain scales.Frontiers in computational neuroscience · 2015Review
- Movement dependence and layer specificity of entorhinal phase precession in two-dimensional environments.PloS one · 2014Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatial information about the environment is encoded by the activity of place and grid cells in the hippocampal formation. As an animal traverses a cell's firing field, action potentials progressively shift to earlier phases of the theta oscillation (6-10 Hz). This "phase precession" is observed also in the prefrontal cortex and the ventral striatum, but mechanisms for its generation are unknown. However, once phase precession exists in one region, it might also propagate to downstream regions. Using a computational model, we analyze such inheritance of phase precession, for example, from the entorhinal cortex to CA1 and from CA3 to CA1. We find that distinctive subthreshold and suprathreshold features of the membrane potential of CA1 pyramidal cells (Harvey et al., 2009; Mizuseki et al., 2012; Royer et al., 2012) can be explained by inheritance and that excitatory input is essential. The model explains how inhibition modulates the slope and range of phase precession and provides two main testable predictions. First, theta-modulated inhibitory input to a CA1 pyramidal cell is not necessary for phase precession. Second, theta-modulated inhibitory input on its own generates membrane potential peaks that are in phase with peaks of the extracellular field. Furthermore, we suggest that the spatial distribution of field centers of a population of phase-precessing input cells determines, not only the place selectivity, but also the characteristics of phase precession of the targeted output cell. The inheritance model thus can explain why phase precession is observed throughout the hippocampal formation and other areas of the brain.
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